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CD79A — PARP1
Text-mined interactions from Literome
Gold et al., Immunol Rev 2000
:
In this review, we discuss the
role of phosphatidylinositol 3-kinase (PI3K) and
Rap 1 in
B-cell receptor (BCR) signaling ... We showed that the
BCR activates
Rap1 via phospholipase C-dependent production of diacylglycerol
Mizuchi et al., Biochem Biophys Res Commun 2005
:
Here we demonstrate that the inducible expression of
BCR/ABL in a murine hematopoietic cell line, TonB210,
leads to the activation of the Ras family small GTPase
Rap1 , which is inhibited by the ABL kinase inhibitor imatinib
Shockett et al., J Immunol 1993
:
In studies aimed at identifying other signaling pathways that promote switching, we discovered that inhibitors of the nuclear enzyme poly ( ADP-ribose ) polymerase (
PARP )
increase LPS induced switching to
IgA in the B cell lymphoma 1.29 mu and to IgG1 in LPS + IL-4 treated splenic B cells
McLeod et al., J Biol Chem 1998
:
In this report, we show that
BCR engagement
activates Rap1 and that this is dependent on production of diacylglycerol ( DAG ) by phospholipase C-gamma ... However, the DAG dependent pathway by which the
BCR activates
Rap1 apparently does not involve Crk signaling complexes since phorbol dibutyrate could activate Rap1 without inducing the formation of these complexes ... Thus, the
BCR activates
Rap1 via a novel DAG dependent pathway