◀ Back to CD4
CD274 — CD4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Schreiner et al., J Neuroimmunol 2004
(Multiple Sclerosis) :
Importantly,
B7-H1 expressed on APC strongly
inhibits autologous
CD4 T-cell activation
Salih et al., Exp Hematol 2006
(Leukemia) :
In contrast to various other tumor entities and the data reported from a murine leukemia system, no significant inhibitory
effect of leukemia derived
B7-H1 on
CD4 and CD8 cytokine production ( IFN-gamma, IL-2 ), proliferation or expression of T-cell activation markers ( ICOS, CD69 ) was observed
Kuipers et al., Eur J Immunol 2006
:
In this study we examined the
role of
PD-L1 and PD-L2 expressed by DC in naïve
CD4+ T cell activation in a more physiologically relevant model system, using OVA-specific T cells in combination with various levels of TCR stimulation
Jeon et al., Xenotransplantation 2007
:
Moreover, porcine
PD-L1 expressed on Chinese hamster ovary ( CHO ) cells
inhibited human
CD4 ( + ) T cell proliferation stimulated with anti-CD3 only or anti-CD3 plus anti-CD28 ... Moreover, porcine
PD-L1 inhibited human
CD4 ( + ) T cell activation in human PD-1 dependent manner, and this involved activated T cell apoptosis
Guleria et al., Clin Immunol 2007
(Diabetes Mellitus, Type 1) :
Administration of blocking anti-PDL1 antibody to CD4+ T cell-deficient, CD8+ T cell-deficient and B cell-deficient mice demonstrated that
PDL1 mediated regulation of autoreactive
CD4+ and CD8+ T cells is critical for diabetes development
Kasagi et al., J Immunol 2010
(Nephritis) :
Conversely, blocking
PD-L1 using an anti-PD-L1 mAb
increased the number of
CD4 ( + ) PD-1 ( + ) T cells in the kidney, enhanced serum IFN-gamma, IL-10, and IgG2a ds-DNA-Ab levels, accelerated the nephritis, and increased the mortality rate
Charles et al., Infect Immun 2010
:
CD4 T-cell suppression by cells from Toxoplasma gondii infected retinas is
mediated by surface protein
PD-L1