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S100B — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Scotto et al., Mol Cell Biol 1999
(Calcium Signaling) :
Concerted regulation of wild-type
p53 nuclear accumulation and
activation by
S100B and calcium dependent protein kinase C ... We first confirmed that
S100B expression in mouse embryo fibroblasts
enhanced specific nuclear accumulation of wild-type
p53
Rustandi et al., Nat Struct Biol 2000
:
A Ca2+ dependent conformational change in dimeric
S100B ( betabeta ) is
required for it to bind
p53 and inhibit phosphorylation of this tumor suppressor in its C-terminal negative regulatory domain
Lin et al., J Biol Chem 2004
(Melanoma) :
Down-regulation of
p53 in primary malignant melanoma cells is likely the
result of a direct interaction with
S100B , which was observed by co-immunoprecipitation experiments
Fernandez-Fernandez et al., Proc Natl Acad Sci U S A 2005
:
Because the trafficking of p53 depends on its oligomerization state, we suggest that
S100B and S100A4 could
regulate the subcellular localization of
p53
Gilquin et al., Mol Cell Biol 2010
:
Such a function for S100B might also help to explain the rescue of nuclear translocation and
activation of the temperature-sensitive
p53val135 mutant by
S100B at nonpermissive temperatures
McDowell et al., J Mol Biol 2013
:
Calcium dependent binding of dimeric
S100B ( ßß ) to p53-NRD blocks access to these PTM sites and
disrupts the
p53 tetramer to inhibit p53 activation