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TP53 — USP7

Pathways - manually collected, often from reviews:

• NCI Pathway Database p53 pathway: USP7 (USP7) → p53 (TP53) (modification, activates) Marchenko et al., EMBO J 2007
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: USP7 — TP53 Meulmeester et al., Mol Cell 2005*
• IRef Bind_translation Interaction: USP7 — TP53 (coimmunoprecipitation) Meulmeester et al., Mol Cell 2005*
• IRef Biogrid Interaction: USP7 — TP53 (physical association, affinity chromatography technology) Li et al., Nature 2002*
• IRef Biogrid Interaction: USP7 — TP53 (direct interaction, enzymatic study) Li et al., Nature 2002*
• IRef Biogrid Interaction: USP7 — TP53 (direct interaction, pull down) Brooks et al., Oncogene 2007*
• IRef Biogrid Interaction: USP7 — TP53 (physical association, affinity chromatography technology) Brooks et al., Oncogene 2007*
• IRef Biogrid Interaction: USP7 — TP53 (physical association, affinity chromatography technology) Becker et al., Cell Death Differ 2007*
• IRef Biogrid Interaction: USP7 — TP53 (direct interaction, unspecified method) Hu et al., PLoS Biol 2006*
• IRef Biogrid Interaction: USP7 — TP53 (association, x-ray crystallography) Hu et al., PLoS Biol 2006*
• IRef Biogrid Interaction: USP7 — TP53 (direct interaction, unspecified method) Sarkari et al., J Mol Biol 2010*
• IRef Biogrid Interaction: USP7 — TP53 (physical association, affinity chromatography technology) Marchenko et al., EMBO J 2007
• IRef Biogrid Interaction: USP7 — TP53 (physical association, affinity chromatography technology) Epping et al., Nat Cell Biol 2011*
• IRef Biogrid Interaction: USP7 — TP53 (physical association, affinity chromatography technology) Qing et al., J Cell Biochem 2011*
• IRef Biogrid Interaction: USP7 — TP53 (physical association, affinity chromatography technology) Tang et al., Nat Cell Biol 2006
• IRef Biogrid Interaction: USP7 — TP53 (direct interaction, pull down) Ma et al., Arch Biochem Biophys 2010*
• IRef Biogrid Interaction: USP7 — TP53 (physical association, affinity chromatography technology) Dai et al., Proc Natl Acad Sci U S A 2011*
• IRef Biogrid Interaction: USP7 — TP53 (direct interaction, unspecified method) Holowaty et al., J Biol Chem 2003*
• IRef Biogrid Interaction: USP7 — TP53 (direct interaction, pull down) Sheng et al., Nature structural & molecular biology 2006*
• IRef Biogrid Interaction: USP7 — TP53 (association, x-ray crystallography) Sheng et al., Nature structural & molecular biology 2006*
• IRef Biogrid Interaction: USP7 — TP53 (direct interaction, unspecified method) Sheng et al., Nature structural & molecular biology 2006*
• IRef Biogrid Interaction: USP7 — TP53 (direct interaction, enzymatic study) Yi et al., Genes Dev 2013*
• IRef Biogrid Interaction: USP7 — TP53 (physical association, affinity chromatography technology) Yi et al., Genes Dev 2013*
• IRef Dip Interaction: USP7 — TP53 (direct interaction, molecular sieving) Hu et al., PLoS Biol 2006*
• IRef Dip Interaction: USP7 — TP53 (direct interaction, x-ray crystallography) Sheng et al., Nature structural & molecular biology 2006*
• IRef Dip Interaction: USP7 — TP53 (direct interaction, isothermal titration calorimetry) Hu et al., PLoS Biol 2006*
• IRef Dip Interaction: USP7 — TP53 (direct interaction, nuclear magnetic resonance) Sheng et al., Nature structural & molecular biology 2006*
• IRef Dip Interaction: USP7 — TP53 (direct interaction, classical fluorescence spectroscopy) Sheng et al., Nature structural & molecular biology 2006*
• IRef Dip Interaction: USP7 — TP53 (direct interaction, pull down) Sheng et al., Nature structural & molecular biology 2006*
• IRef Hprd Interaction: TP53 — USP7 (in vivo) Li et al., Nature 2002*, Sheng et al., Nature structural & molecular biology 2006*
• IRef Hprd Interaction: TP53 — USP7 (in vitro) Li et al., Nature 2002*, Sheng et al., Nature structural & molecular biology 2006*
• IRef Intact Interaction: USP7 — TP53 (physical association, coimmunoprecipitation) Li et al., Nature 2002*
• IRef Intact Interaction: USP7 — TP53 (deubiquitination reaction, experimental interaction detection) Li et al., Nature 2002*
• IRef Intact Interaction: USP7 — TP53 (direct interaction, pull down) Li et al., Nature 2002*
• IRef Intact Interaction: USP7 — TP53 (physical association, anti bait coimmunoprecipitation) Meulmeester et al., Mol Cell 2005*
• IRef Intact Interaction: USP7 — TP53 (physical association, classical fluorescence spectroscopy) Sheng et al., Nature structural & molecular biology 2006*
• IRef Intact Interaction: USP7 — TP53 (direct interaction, x-ray crystallography) Sheng et al., Nature structural & molecular biology 2006*
• IRef Intact Interaction: USP7 — TP53 (physical association, pull down) Sheng et al., Nature structural & molecular biology 2006*
• IRef Intact Interaction: USP7 — TP53 (physical association, nuclear magnetic resonance) Sheng et al., Nature structural & molecular biology 2006*
• IRef Intact Interaction: USP7 — TP53 (physical association, anti bait coimmunoprecipitation) Marchenko et al., EMBO J 2007
• IRef Intact Interaction: USP7 — TP53 (physical association, anti tag coimmunoprecipitation) Epping et al., Nat Cell Biol 2011*
• IRef Intact Interaction: Complex of 17 proteins (association, anti bait coimmunoprecipitation) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of 26 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 244 proteins (association, pull down) Komarova et al., Mol Cell Proteomics 2011
• IRef Intact Interaction: Complex of USP7-TP53 (association, anti bait coimmunoprecipitation) Meulmeester et al., Mol Cell 2005*
• IRef Intact Interaction: Complex of USP7-TP53-MDM2-MDM4 (association, anti bait coimmunoprecipitation) Meulmeester et al., Mol Cell 2005*
• IRef Intact Interaction: Complex of 50 proteins (association, anti tag coimmunoprecipitation) Coffill et al., EMBO Rep 2012
• IRef Intact Interaction: Complex of USP7-MDM4-TP53-USP7-MDM4-TP53 (association, anti bait coimmunoprecipitation) Meulmeester et al., Mol Cell 2005*
• IRef Ophid Interaction: USP7 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: USP7 — TP53 (aggregation, confirmational text mining) Li et al., Nature 2002*

Text-mined interactions from Literome

Li et al., Mol Cell 2004 (Bone Neoplasms) : Our previous study showed that ubiquitination of p53 is reversible and that the ubiquitin hydrolase HAUSP can stabilize p53 by deubiquitination
Cummins et al., Cell cycle (Georgetown, Tex.) 2004 : Rather than decreasing p53 levels associated with increased p53 ubiquitination, the absence of HAUSP resulted in p53 accumulation accompanied by decreased p53 ubiquitination
Hu et al., PLoS Biol 2006 : HAUSP preferentially forms a stable HAUSP-MDM2 complex even in the presence of excess p53
Becker et al., Cell Death Differ 2007 (Neuroblastoma) : Instead, the defect lies in p53 regulation by HAUSP , a major p53 deubiquitylating enzyme
Kon et al., Oncogene 2010 : Interestingly, knockout or RNA interference mediated knockdown of Hausp in human cells also resulted in the stabilization of p53 due to the destabilization of Mdm2, suggesting a dynamic role of Hausp in p53 activation
Sarkari et al., PloS one 2010 : USP7/HAUSP promotes the sequence-specific DNA binding activity of p53
Khoronenkova et al., Nucleic Acids Res 2011 : USP7 is involved in the cellular stress response by regulating Mdm2 and p53 protein levels following severe DNA damage
Kon et al., Cell Death Differ 2011 : Roles of HAUSP mediated p53 regulation in central nervous system development ... These results indicate that HAUSP mediated p53 regulation is crucial for brain development, and also suggest that both the p53 dependent and the p53 independent functions of HAUSP contribute to the neonatal lethality of hausp-mutant mice
Thalappilly et al., PloS one 2011 : We also find that ING1 physically interacts with herpesvirus associated ubiquitin-specific protease ( HAUSP ), a p53 and MDM2 deubiquitinase ( DUB ), and knockdown of HAUSP blocks the ability of ING1 to stabilize p53
Kim et al., Mol Cell 2011 : The functional consequences of DNA damage induced RORa are to stabilize p53 and activate p53 transcription in a HAUSP/Usp7 dependent manner
Khoronenkova et al., Mol Cell 2012 : ATM dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
Bougdour et al., Cell Host Microbe 2013 : GRA16 alters p53 levels in a HAUSP dependent manner and induces nuclear translocation of the PP2A holoenzyme