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CDH1 — SMAD2
Text-mined interactions from Literome
Medici et al., Mol Biol Cell 2006
:
However, our results also demonstrate that a complete loss of
E-cadherin and transformation to the mesenchymal phenotype are
dependent on
Smad signaling, which subsequently stimulates formation of beta-catenin/LEF-1 complexes that induce EMT
Kolosova et al., J Cell Physiol 2011
:
However, neither
Smad2/3 nor p38 MAPK were
required for the down-regulation of
E-cadherin , yet p38 MAPK was associated with fibronectin up-regulation
Liu et al., J Agric Food Chem 2012
(Carcinoma, Non-Small-Cell Lung...) :
EGCG decreased the phosphorylation of Smad2 and Erk1/2,
inhibited the nuclear translocation of
Smad2 , and repressed the expression of transcription factors ZEB1, Snail, Slug, and Twist, and up-regulated the expression of
E-cadherin