Yuksel et al., Thromb Haemost 2002
(MAP Kinase Signaling System...) :
APC also inhibited both the binding of activator protein-1 (AP-1) to target sites and the activation of mitogen activated protein kinase pathways ... These observations strongly suggest that APC inhibited LPS induced TNF-alpha production by inhibiting the activation of both NF-kappa B and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity
Okajima et al., Clin Chem Lab Med 2004
(Inflammation) :
APC inhibited ET-induced TNF-alpha production in human monocytes by inhibiting activation of nuclear factor K-B and activator protein-1 in vitro
Okajima et al., Curr Vasc Pharmacol 2004
(Hypotension...) :
APC inhibits ET-induced TNF-alpha production in vitro in human monocytes by inhibiting activation of NFkappaB and AP-1 by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways, respectively