Gene interactions and pathways from curated databases and text-mining

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FSHB — SMAD7

Text-mined interactions from Literome

Bernard et al., Mol Endocrinol 2004 : Overexpression of the inhibitory SMAD7 blocked this effect, as well as activin stimulated FSHbeta transcription
Lau et al., Gen Comp Endocrinol 2005 : Co-transfection of Smad2 or Smad3 cDNA into the LbetaT-2 cells with the reporter construct of goldfish FSHbeta promoter significantly enhanced basal and activin stimulated reporter ( SEAP, secreted alkaline phosphatase ) expression, while Smad7 completely blocked basal and Smad2/3 stimulated FSHbeta activity
Thackray et al., Endocrinology 2008 : Disruption of Smad binding to the promoter with a Smad protein lacking the DNA binding domain or an FSHbeta promoter containing mutated activin-response elements prevents the synergistic enhancement of FSHbeta transcription