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FSHB — SMAD7
Text-mined interactions from Literome
Bernard et al., Mol Endocrinol 2004
:
Overexpression of the inhibitory
SMAD7 blocked this effect, as well as activin stimulated
FSHbeta transcription
Lau et al., Gen Comp Endocrinol 2005
:
Co-transfection of Smad2 or Smad3 cDNA into the LbetaT-2 cells with the reporter construct of goldfish FSHbeta promoter significantly enhanced basal and activin stimulated reporter ( SEAP, secreted alkaline phosphatase ) expression, while
Smad7 completely
blocked basal and Smad2/3 stimulated
FSHbeta activity
Thackray et al., Endocrinology 2008
:
Disruption of
Smad binding to the promoter with a Smad protein lacking the DNA binding domain or an FSHbeta promoter containing mutated activin-response elements
prevents the synergistic enhancement of
FSHbeta transcription