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Trevisan et al., Exp Cell Res 2004
:
As Tax can enhance the transcriptional activity of nuclear factor NF-kB and cAMP-responsive element binding protein/activating transcription factor-1 ( CREB/ATF-1 ), we investigated the relevance of these routes in the anti-apoptotic effects of Tax
Kwon et al., J Biol Chem 2005
(Inflammation...) :
To study initiating events involved in HTLV-I Tax induced T cell transformation, we generated `` Tet-off '' transgenic mice conditionally expressing in a lymphocyte restricted manner ( EmuSR alpha promoter-enhancer ) either wild-type Tax or mutant forms of Tax that selectively compromise the NF-kappaB ( M22 ) or CREB/activating transcription factor ( M47 ) activation pathways