◀ Back to CTNNB1

CTNNB1 — SNAI2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: LEF1/beta catenin complex (LEF1-CTNNB1) → SLUG (SNAI2) (transcription, activates) Lambertini et al., BMC molecular biology 2010*
  Evidence: reporter gene, physical interaction

Text-mined interactions from Literome

Conacci-Sorrell et al., J Cell Biol 2003 (Cell Transformation, Neoplastic...) : Slug was induced by beta-catenin signaling and, independently, by ERK
Medici et al., Mol Biol Cell 2008 : Here, we show that Snail and Slug promote formation of beta-catenin-T-cell factor (TCF)-4 transcription complexes that bind to the promoter of the TGF-beta3 gene to increase its transcription
Lambertini et al., BMC molecular biology 2010 : We found that SLUG is positively correlated with RUNX2 expression and deposition of mineralized matrix, and is regulated by Lef-1 and beta-catenin