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IL15 — IL17A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ziolkowska et al., J Immunol 2000
(Arthritis, Rheumatoid...) :
High levels of IL-17 in rheumatoid arthritis patients :
IL-15 triggers in vitro
IL-17 production via cyclosporin A-sensitive mechanism
Hwang et al., Arthritis Res Ther 2004
(Arthritis, Rheumatoid) :
IL-17 enhanced the production of IL-6 and IL-8 in FLS, as previously shown, but did not
affect the synthesis of
IL-15
Cho et al., Immunol Lett 2007
(Arthritis, Rheumatoid) :
Cyclosporine A inhibits
IL-15 induced
IL-17 production in CD4+ T cells via down-regulation of PI3K/Akt and NF-kappaB ... Cyclosporine A ( CSA ) has various biological effects on T cells, including inhibition of
interleukin (IL)-15 induced
IL-17 production in CD4+ T cells from patients with rheumatoid arthritis ( RA ) ... Here, we tried to investigate the mechanism of CSA to inhibit
IL-17 production
induced by
IL-15 in CD4+ T cells ...
IL-15 induced
IL-17 production by CD4+ T cells in dose- and time dependent manner ... Moreover PI3K/Akt inhibitor, NF-kappaB inhibitor, and FK506 significantly inhibited
IL-15 induced
IL-17 production in CD4+ T cells ... Inhibition studies revealed the requirement of PI3K/Akt and NF-kappaB signal pathway for
IL-15 induced
IL-17 production ... The inhibitory effect of CSA on
IL-15 induced
IL-17 production partially depended on the increase in IL-10, since neutralizing anti-IL-10 antibodies were able to partially reverse this inhibition
Fan et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007
(Autoimmune Diseases) :
IL-2 and
IL-15 induced the production of
IL-17 and IFN-gamma in a dose dependent manner by PBMCs. Similar results were confirmed by ELISPOT assay ... Further study suggested that IL-23, IL-2 and
IL-15 directly
induced the production of
IL-17 and IFN-gamma by purified CD4 ( + ) T cells ... IL-23, IL-2 and
IL-15 can directly
induce CD4 ( + ) T cells to produce
IL-17 and IFN-gamma
Chiba et al., Nihon Rinsho Meneki Gakkai Kaishi 2007
(Arthritis, Experimental...) :
IL-15 activates T cells and
induces IL-17 production whereas IL-17 stimulates synoviocytes to release several mediators of inflammation including IL-6, TNF-alpha, IL-8, and CCL2 ... Based on these results, we investigated a new anti-rheumatic drug targets IL-15 and IL-17 and found a new pyrazoleanilide derivative, Y-320 that inhibits
IL-15 induced
IL-17 production by T cells at 10-nM order
Freches et al., Clinical and vaccine immunology : CVI 2011
(Tuberculosis) :
Increased pulmonary tumor necrosis factor alpha,
interleukin-6 (IL-6), and
IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated, Mycobacterium bovis BCG vaccinated mice