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CTNNB1 — PTPN1

Pathways - manually collected, often from reviews:

• KEGG Adherens junction: PTPN1 → CTNNB1 (protein-protein, activation)
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: PTP1B (PTPN1) → beta catenin/alpha catenin complex (CTNNB1-CTNNA1) (modification, activates)
  Xu et al., J Biol Chem 2002, Xu et al., J Cell Sci 2004, Tai et al., Neuron 2007, Balsamo et al., J Cell Biol 1998
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — PTPN1 (direct interaction, pull down) Xu et al., J Biol Chem 2002
• IRef Hprd Interaction: CTNNB1 — PTPN1 (in vivo) Xu et al., J Biol Chem 2002
• IRef Intact Interaction: Complex of 156 proteins (association, anti tag coimmunoprecipitation) Lau et al., Cell 2012
• IRef Ophid Interaction: CTNNB1 — PTPN1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Lilien et al., Dev Dyn 2002 : Our laboratory has focused on the role of the nonreceptor tyrosine phosphatase PTP1B in regulating the phosphorylation of beta-catenin on tyrosine residues
Xu et al., J Cell Sci 2004 : We now show that the phosphorylation of beta-catenin is regulated by the combined activities of the tyrosine kinase Fer and the tyrosine phosphatase PTP1B