◀ Back to CASP10
CASP10 — SLC9A1
Text-mined interactions from Literome
Manucha et al., BJU Int 2007
(Ureteral Obstruction) :
NHE1 inhibition by increasing doses of EIPA induced epithelial cell apoptosis and
increased caspase-3 activity in a dose dependent manner
Jhumka et al., Int J Biochem Cell Biol 2009
:
We report that the chemopreventive agent resveratrol ( RSV ) downregulates
NHE-1 in a
caspase dependent manner without inducing cell death ... RNAi mediated silencing of
caspase 3 or 6
blocked the effect of resveratrol on
NHE-1 expression, however the effect on NHE-1 promoter was observed at different phases of promoter repression with caspase 3 controlling the early phase ( 4-12 h ) and caspase 6 regulating the late phase ( 12-24 h )
Lauritzen et al., Exp Cell Res 2010
(Breast Neoplasms) :
NHE1 inhibition
augmented cisplatin induced
caspase activity and lysosomal membrane permeability followed by cysteine cathepsin release