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IRS2 — LEP

Pathways - manually collected, often from reviews:

• Reactome Reaction: IRS2 → LEP (reaction) Duan et al., J Biol Chem 2004, Li et al., Mol Endocrinol 2007
• Reactome Reaction: IRS2 → LEP (indirect_complex) Szanto et al., Proc Natl Acad Sci U S A 2000, Martín-Romero et al., Cell Immunol 2001, Duan et al., J Biol Chem 2004, Li et al., Mol Endocrinol 2007, Hill et al., J Clin Invest 2008, Buettner et al., Nat Med 2008, Bjørbaek et al., J Biol Chem 1997

Text-mined interactions from Literome

Carvalheira et al., Biol Chem 2003 : This phenomenon parallels the leptin induced tyrosine phosphorylation of STAT3, STAT5b, IRS-1 and IRS-2
Duan et al., J Biol Chem 2004 : Here we report that SH2-B, a JAK2 interacting protein, promotes activation of the PI 3-kinase pathway by recruiting insulin receptor substrate 1 (IRS1) and IRS2 in response to leptin ... Consequently, SH2-B dramatically enhanced leptin stimulated tyrosine phosphorylation of IRS1 and IRS2 in HEK293 cells stably expressing LRb, thus promoting association of IRS1 and IRS2 with the p85 regulatory subunit of PI 3-kinase and phosphorylation and activation of Akt
Benomar et al., Biochem J 2005 : Furthermore, leptin or insulin pre-treatment increased basal PI3K activity and IRS-1 or IRS-2 association with p85 and abolished acute insulin or leptin effect, in addition to the down-regulation of IRS-1 and IRS-2
Ren et al., Cell Metab 2005 (Body Weight...) : Leptin stimulated activation of hypothalamic JAK2 and phosphorylation of hypothalamic STAT3 and IRS2 were significantly impaired in SH2-B ( -/- ) mice
Duan et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010 (Obesity) : SH2B1 dramatically enhanced the leptin stimulated tyrosine phosphorylation of JAK2 and IRS2 in HEK293 cells stably expressing LRb ( HEK239 ( LRb ) ) ... Leptin stimulated activation of hypothalamic JAK2 and phosphorylation of hyphothalamic IRS2 were significantly impaired in SH2B1 ( -/- ) mice
Nazarians-Armavil et al., Mol Endocrinol 2013 : Neuronal insulin resistance, as assessed by attenuated Akt phosphorylation, blocked leptin mediated signal transduction and agouti related peptide, urocortin-2, IRS1, IRS2 , and insulin receptor synthesis
Kellerer et al., Diabetologia 1997 : Since we have also detected leptin stimulated tyrosine phosphorylation of JAK-2 and IRS-2 in C2C12 myotubes it can be assumed that leptin activates JAK-2 which induces tyrosine phosphorylation of IRS-2 leading to activation of PI-3 kinase