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ATOH1 — NOTCH2
Text-mined interactions from Literome
Kazanjian et al., Gastroenterology 2010
(Colorectal Neoplasms) :
ATOH1 is required for all effects of GSIs in intestinal crypts and adenomas ;
Notch has no unique function in intestinal progenitors and cancer cells other than to
regulate ATOH1 expression
Kelly et al., J Neurosci 2012
:
Significantly,
Atoh1 induces ectopic sensory patches through
Notch signaling to form a cellular mosaic similar to the endogenous sensory epithelia and expansion of the sensory mosaic through the conversion of supporting cells and nonautonomous supporting cell production
Mizutari et al., Neuron 2013
(Hearing Loss, Noise-Induced) :
Hair cell generation resulted from an increase in the level of bHLH transcription factor
Atoh1 in
response to inhibition of
Notch signaling