◀ Back to JAK2
JAK2 — TYK2
Pathways - manually collected, often from reviews:
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
→
STAT4
(modification, activates)
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BioCarta stat3 signaling pathway:
Stat3 activating cytokines/cytokine receptor/JAKs/TYK2 complex (JAK2_JAK1_JAK3-TYK2)
→
STAT3
(modification, activates)
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12 (IL12B/IL12A)
→
IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12 (IL12B/IL12A)
→
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
(modification, collaborate)
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-TYK2-JAK2)
→
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
(modification, collaborate)
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BioCarta stat3 signaling pathway:
Stat3 activating cytokines/cytokine receptor/JAKs/TYK2 complex (JAK2_JAK1_JAK3-TYK2)
→
Cytokine receptor/JAKs/TYK2 complex (TYK2-JAK2_JAK1_JAK3)
(modification, collaborate)
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NCI Pathway Database IL12-mediated signaling events:
STAT4 (STAT4)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Chin et al., Nature 2002, Bacon et al., Proc Natl Acad Sci U S A 1995, Jacobson et al., J Exp Med 1995, Naeger et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
RIP2 (RIPK2)
(modification, activates)
Chin et al., Nature 2002, Bacon et al., Proc Natl Acad Sci U S A 1995, Jacobson et al., J Exp Med 1995, Naeger et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (STAT3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002, Cho et al., J Immunol 2006
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, activates)
Parham et al., J Immunol 2002, Cho et al., J Immunol 2006
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
Granzyme A (GZMA)
(transcription, activates)
Salcedo et al., J Immunol 1993
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Jacobson et al., J Exp Med 1995, Zou et al., J Biol Chem 1997
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT3 (dimer)-active complex (STAT3)
(modification, activates)
Jacobson et al., J Exp Med 1995, Zou et al., J Biol Chem 1997
Evidence: assay, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT1 (STAT1)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL23-mediated signaling events:
SOCS3 (SOCS3)
→
IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3)
(modification, collaborate)
Chen et al., Proc Natl Acad Sci U S A 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
SOCS3 (SOCS3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Chen et al., Proc Natl Acad Sci U S A 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Chen et al., Proc Natl Acad Sci U S A 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Kusaba et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
mTOR (MTOR)
(modification, activates)
Kusaba et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
LCK (LCK)
(modification, activates)
Pignata et al., Cell Immunol 1995
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
STAT1 (STAT1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IFN-gamma (IFNG)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT1 (dimer) complex (STAT1)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT6 (STAT6)
(modification, activates)
Moriggl et al., J Immunol 1998
Evidence: assay
-
NCI Pathway Database IL27-mediated signaling events:
STAT1 (STAT1)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
MIP1B (CCL4)
(transcription, activates)
Galon et al., J Immunol 1999
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Rodriguez-Galán et al., J Immunol 2005
Evidence: assay, other species
-
NCI Pathway Database IL27-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(transcription, activates)
Chen et al., Nature 2000, Yoshida et al., Immunity 2001, Pflanz et al., Immunity 2002, Kamiya et al., J Immunol 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL2 (IL2)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, activates)
Parham et al., J Immunol 2002
-
NCI Pathway Database IL23-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, activates)
Parham et al., J Immunol 2002
-
NCI Pathway Database IL12-mediated signaling events:
STAT4 (STAT4)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: reporter gene
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
→
STAT4 (dimer) complex (STAT4)
(modification, activates)
Yoshimoto et al., J Immunol 2003
Evidence: reporter gene
-
NCI Pathway Database IL27-mediated signaling events:
STAT5A (STAT5A)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT4 (STAT4)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database IL27-mediated signaling events:
IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2)
→
IL27/EBI3 complex (IL27-EBI3)
(modification, collaborate)
Pflanz et al., J Immunol 2004
Evidence: functional complementation
-
NCI Pathway Database IL27-mediated signaling events:
IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
Pflanz et al., J Immunol 2004
Evidence: functional complementation
-
NCI Pathway Database IL27-mediated signaling events:
IL27/EBI3 complex (IL27-EBI3)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
Pflanz et al., J Immunol 2004
Evidence: functional complementation
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (STAT3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
STAT4 (STAT4)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL1 beta (IL1B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, activates)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Takemoto et al., J Immunol 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL23 complex (IL23A-IL12B)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL23R/JAK2 complex (IL23R-JAK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL23R/JAK2 complex (IL23R-JAK2)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
p38 alpha (MAPK14)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
SPHK2 (SPHK2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
SPHK2 (SPHK2)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT5A (STAT5A)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IFN-gamma (IFNG)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Schindler et al., J Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT1 (STAT1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
p38 alpha (MAPK14)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL27-mediated signaling events:
STAT3 (STAT3)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
Calcineurin A alpha-beta B1 ()
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, inhibits)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, activates)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
NOS2 (NOS2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, activates)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL27-mediated signaling events:
STAT2 (STAT2)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
NF kappa B2 p52/RelB complex (NFKB2-RELB)
(translocation, activates)
Grohmann et al., Immunity 1998
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
HLX1 (HLX)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT4 (dimer) complex (STAT4)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL27-mediated signaling events:
STAT4 (STAT4)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
SOCS1 (SOCS1)
→
IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
SOCS1 (SOCS1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
IFN-gamma (IFNG)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, inhibits)
Langrish et al., J Exp Med 2005, Harrington et al., Nat Immunol 2005
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT5A (STAT5A)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Doucet et al., Oncogene 2000
(Lung Neoplasms...) :
In normal cells, we
detected the activation of the classic IRS-2 or JAK1/STAT6 pathways, the phosphorylation of
JAK2 , while
Tyk2 was constitutively phosphorylated and not modified by both cytokines
Lukashova et al., J Immunol 2003
:
Janus kinase 2 activation by the platelet activating factor receptor ( PAFR ) :
roles of
Tyk2 and PAFR C terminus ... Moreover,
Tyk2-K930I completely
blocked PAF stimulated
Jak2 phosphorylation
Shang et al., Cancer Sci 2007
(Carcinoma, Renal Cell...) :
The results suggest that the resistance of RCC to IFN-alpha is associated with the lack of Jak1,
Tyk2 and Stat1 expression and defective
Jak-Stat activation , but not with a lack of IFN-alpha receptor, suppressors of cytokine signaling induction or other factors examined
Simmons et al., J Virol 2009
:
Furthermore, at times when STAT1 activation was efficiently inhibited, VRP infection did not limit tyrosine phosphorylation of Jak1,
Tyk2 , or STAT2 after IFN-beta treatment but did
inhibit Jak1 and
Jak2 activation in response to IFN-gamma, suggesting that VEEV interferes with STAT1 activation by the type I and II receptor complexes through distinct mechanisms
Dedoni et al., J Neurochem 2010
(Neuroblastoma) :
Janus kinase inhibition
reduced IFN-ß stimulated
TyK2 and STAT1 phosphorylation, STAT1 transcriptional activity, induction of double stranded RNA activated protein kinase ( PKR ) and caspase cleavage
Bhattacharjee et al., Free Radic Biol Med 2013
:
We further show that
Jak2 is upstream of Stat3 activation and
Tyk2 controls Stat1 and Stat6 activation in response to IL-13 stimulation
Shuai et al., Nature 1993
:
Somatic cell genetics experiments have demonstrated a
requirement for
tyrosine kinase-2 (Tyk2) in the IFN-alpha response pathway and for
Jak2 ( ref. 6 ), a kinase with similar sequence, in the IFN-gamma response pathway
Murata et al., J Biol Chem 1995
(Colonic Neoplasms) :
The phosphorylation of JAK1 and
JAK2 was
induced by IL-4 stimulation ; however,
Tyk2 was constitutively phosphorylated, and IL-4 treatment further augmented this phosphorylation
Pan et al., Circ Res 1997
(Acute Disease...) :
Both cilazapril ( angiotensin II-converting enzyme inhibitor ) and E4177 ( angiotensin II type 1 [ AT1 ] receptor antagonist ) significantly suppressed the phosphorylation of
Tyk2 and partially
inhibited the phosphorylation of
JAK2 , but neither affected JAK1