Gene interactions and pathways from curated databases and text-mining

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IRF6 — VIP

Text-mined interactions from Literome

Kojima et al., Pancreas 2005 (Acute Disease...) : In vitro, IL-6 and TNF-alpha production by monocytes from the spleen was determined under the stimulation of LPS with VIP , VPAC1-R agonist, or VPAC2-R agonist, and the expression of VPAC1-R and VPAC2-R mRNA in monocytes was examined
Ait-Ali et al., Neuropharmacology 2010 : Messenger RNAs encoding vasoactive intestinal polypeptide (VIP) and galanin, both modulators of steroidogenesis in neighboring adrenal cortex, are up-regulated at 24 h ( eight-fold for VIP and two-fold for galanin ) after LPS injection, and remain elevated for the following 24 h. Up-regulation of VIP and galanin by LPS is abrogated in pituitary adenylate cyclase activating polypeptide ( PACAP ) -deficient mice, suggesting an interaction between LPS, or LPS induced cytokines, and PACAP released in adrenal medulla from the splanchnic nerve
Delgado et al., J Immunol 1999 (Inflammation) : The immunomodulatory role of VIP in vivo is supported by the up-regulation of VIP release in serum and peritoneal fluid by LPS and proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6