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IRF6 — VIP
Text-mined interactions from Literome
Kojima et al., Pancreas 2005
(Acute Disease...) :
In vitro, IL-6 and TNF-alpha production by monocytes from the spleen was determined under the
stimulation of
LPS with
VIP , VPAC1-R agonist, or VPAC2-R agonist, and the expression of VPAC1-R and VPAC2-R mRNA in monocytes was examined
Ait-Ali et al., Neuropharmacology 2010
:
Messenger RNAs encoding vasoactive intestinal polypeptide (VIP) and galanin, both modulators of steroidogenesis in neighboring adrenal cortex, are up-regulated at 24 h ( eight-fold for VIP and two-fold for galanin ) after LPS injection, and remain elevated for the following 24 h.
Up-regulation of
VIP and galanin by
LPS is abrogated in pituitary adenylate cyclase activating polypeptide ( PACAP ) -deficient mice, suggesting an interaction between LPS, or LPS induced cytokines, and PACAP released in adrenal medulla from the splanchnic nerve
Delgado et al., J Immunol 1999
(Inflammation) :
The immunomodulatory role of VIP in vivo is supported by the
up-regulation of
VIP release in serum and peritoneal fluid by
LPS and proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6