Gene interactions and pathways from curated databases and text-mining

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CHUK — EPHB2

Text-mined interactions from Literome

Chen et al., Br J Pharmacol 2001 : PKC- and ERK dependent activation of I kappa B kinase by lipopolysaccharide in macrophages : enhancement by P2Y receptor mediated CaMK activation
Afaq et al., Int J Cancer 2005 (Edema...) : We also found that topical application of PFE resulted in inhibition of TPA induced phosphorylation of ERK1/2 , p38 and JNK1/2, as well as activation of NF-kappaB and IKKalpha and phosphorylation and degradation of IkappaBalpha
Maeng et al., Cell Signal 2006 : Consistently, inhibition of ERK significantly increased IkappaB kinase (IKK) activity, IkappaBalpha phosphorylation, and nuclear translocation of NF-kappaB induced by VEGF, whereas overexpression of ERK resulted in the loss of these responses to VEGF
Shan et al., Am J Physiol Lung Cell Mol Physiol 2006 (Asthma...) : Complementary studies further demonstrated that the ASM responses to LPS were associated with activation of the ERK1/2 and p38 MAPK signaling pathways, IKK mediated activation of NF-kappaB, and coupling of phosphorylated ERK1/2 with the p65 subunit of NF-kappaB
Huang et al., Biochem Pharmacol 2007 (Lung Neoplasms) : The SDF-1alpha mediated increases in IKK alpha/beta phosphorylation, p65 Ser ( 536 ) phosphorylation, and kappaB-luciferase activity were inhibited by PD98059 and ERK2 mutant
Otipoby et al., Proc Natl Acad Sci U S A 2008 : BAFF activates Akt and Erk through BAFF-R in an IKK1 dependent manner in primary mouse B cells
Leghmari et al., Eur J Cell Biol 2008 : We demonstrate that, upstream of NF-kappaB, PKC, ERK1/2 and p38 MAP kinases are involved in Tat induced IKKalpha nuclear translocation and histone H3 modifications on the IL-10 promoter in accordance with the role of these three kinases in IL-10 production
Chen et al., TheScientificWorldJournal 2010 : Blocking phosphorylation of ERK1/2 by MAPK inhibitors U0126 and PD98059, and inhibiting activation of NF-?B by IkappaB ( I?B ) kinase inhibitors wedelolactone or IMD-0354, abolished the DSP effects
Yang et al., Mol Cell Biol 2012 : Unexpectedly, TPL-2 promoted soluble TNF production independently of IKK induced p105 phosphorylation and its ability to activate ERK , which has important implications for the development of anti-inflammatory drugs targeting TPL-2
Slomiany et al., Inflammopharmacology 2013 : Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on MAPK/ERK mediated activation of IKK-ß and cPLA2 : modulatory effect of ghrelin
Lee et al., Proc Natl Acad Sci U S A 1998 : We have previously shown that mitogen activated protein kinase/ERK kinase kinase 1 ( MEKK1 ) can induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight IkappaB kinase complex in vitro