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CDKN1A — RHO

Text-mined interactions from Literome

Sahai et al., EMBO J 2001 (MAP Kinase Signaling System) : While the elevated levels of Rho-GTP control the level of p21/Waf , they no longer regulate the formation of actin stress fibres in transformed cells
Liberto et al., Oncogene 2002 : Rho regulates p21 ( CIP1 ), cyclin D1, and checkpoint control in mammary epithelial cells ... The Rho inhibitor, C3 exotransferase, induced p21 ( CIP1 ) both in EGF stimulated and V12Ras expressing cells ... Our results demonstrate that Rho plays a fundamental role in promoting Ras dependent S phase entry in mammary epithelial cells, whether in response to normal or oncogenic signaling, and indicate that in cells expressing oncogenic Ras, the activation of Rho diminishes p21 ( CIP1 ) expression, increases cyclin D1 promoter activity, and uncouples DNA synthesis from mitosis
Tanaka et al., J Cell Biol 2002 : Cytoplasmic p21 ( Cip1/WAF1 ) regulates neurite remodeling by inhibiting Rho-kinase activity
Kamaraju et al., J Biol Chem 2005 (Breast Neoplasms...) : We demonstrate that activation of the p38 MAP kinase pathway is necessary for the full transcriptional activation potential of Smad2/Smad3 by TGF-beta, whereas activity of Rho/ROCK is necessary for both down-regulation of c-Myc protein and up-regulation of p21waf1 protein, directly interfering with p21waf1 transcription
Tsai et al., Proc Natl Acad Sci U S A 1985 : p21 GTPase activity was slightly stimulated by rhodopsin , but, in contrast to the GTPase activity of transducin, stimulation was not light dependent