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HIF1A — LEP
Text-mined interactions from Literome
Grosfeld et al., J Biol Chem 2002
(Choriocarcinoma) :
Deletion analysis and site-specific mutagenesis demonstrated that a HIF-1 consensus binding site ( HRE ) spanning -120 to -116 bp relative to the start site was required for CoCl2 and exogenous
HIF-1alpha induction of
leptin promoter activity
Wu et al., Am J Pathol 2007
(Endometriosis) :
A promoter activity assay demonstrated that
HIF-1alpha induced
leptin promoter activity after DFO treatment ... Taken together, our data demonstrate that aberrant expression of
leptin in ectopic endometriotic stromal cells is
induced , at least in part, by an elevated level of
HIF-1alpha in these cells, providing new insights into the etiology of endometriosis
Zhang et al., Zhonghua Yi Xue Za Zhi 2008
(Adenocarcinoma...) :
The expression of
leptin is up-regulated by hypoxia and
regulated by
HIF-1alpha
Gonzalez-Perez et al., Cell Signal 2010
(Mammary Neoplasms, Experimental) :
Deletion analysis of VEGF promoter and RNA knockdown shows that
HIF-1alpha and NFkappaB are
essentials for
leptin regulation of VEGF ...
Leptin activation of
HIF-1alpha was mainly linked to canonic ( MAPK, PI-3K ) and non-canonic ( PKC, JNK and p38 MAP ) signalling pathways