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NOS3 — PPARG

Text-mined interactions from Literome

Neve et al., Biochem Pharmacol 2000 (Arteriosclerosis) : PPAR gamma activation in macrophages and foam cells inhibits the expression of activated genes such as inducible nitric oxide synthase , matrix metalloproteinase-9 and scavenger receptor A. PPAR gamma may also affect the recruitment of monocytes in atherosclerotic lesions as it is involved in the expression of VCAM-1 and intracellular adhesion molecule-1 in vascular endothelial cells
Goetze et al., Hypertension 2002 : Both PPARgamma-ligands inhibited leptin stimulated Akt and eNOS phosphorylation, but neither attenuated ERK 1/2 activation in response to leptin
Mendez et al., Hypertension 2003 : PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes
Crosby et al., J Pharmacol Exp Ther 2005 : Peroxisome proliferation activated receptor ( PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide
Shankaranarayanan et al., Cancer Cell 2009 (Breast Neoplasms) : This `` rexinoid apoptosis '' involves activation of both iNOS and eNOS by RXR-PPARgamma and results in production of apoptogenic NO
Ricote et al., Nature 1998 : Here we show that PPAR-gamma is markedly upregulated in activated macrophages and inhibits the expression of the inducible nitric oxide synthase , gelatinase B and scavenger receptor A genes in response to 15d-PGJ2 and synthetic PPAR-gamma ligands