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CA2 — GRK7
Text-mined interactions from Literome
Diverse-Pierluissi et al., Neuron 1996
(Synaptic Transmission) :
G protein coupled receptor kinase mediates desensitization of norepinephrine induced
Ca2+ channel inhibition
Haga et al., Biochemistry 1997
:
These results indicate that
Ca2+-calmodulin does not directly interact with the catalytic site of GRK2 but
inhibits the kinase activity of
GRK2 by interfering with the activation of GRK2 by agonist bound m2 receptors and G protein betagamma subunits ... In agreement with the assumption that
GRK2 activity is
suppressed by the increase in intracellular
Ca2+ , the sequestration of m2 receptors expressed in Chinese hamster ovary cells was found to be attenuated by the treatment with a Ca2+ ionophore, A23187