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IL10 — IL17A

Text-mined interactions from Literome

Chabaud et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : The secretion of IL-17 by synovium was measured in the presence of IL-4, IL-13, and IL-10
Lenarczyk et al., Clin Exp Immunol 2000 : We therefore investigated the in vitro IL-17 response to a variety of mitogens and antigens, and compared the IL-17 response to interferon-gamma (IFN-gamma), IL-4, IL-10 and TNF-alpha
Vanden Eijnden et al., Eur J Immunol 2005 : IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human
Jarry et al., J Clin Invest 2008 : Depletion of IL-10 in mucosal explants induced both downregulation of the IL-10-inducible, immunosuppressive gene BCL3 and upregulation of IFN-gamma, TNF-alpha, and IL-17
Chang et al., Circ J 2008 (Autoimmune Diseases...) : In the present study, alterations of IL-17 related protein expressions were investigated and then the effect of hydrodynamic based delivery of plasmid DNA encoding the IL-10-Ig gene on rat EAM and the effect of IL-10-Ig on IL-17 was evaluated ... Moreover, we observed that IL-10-Ig gene therapy was effective in controlling EAM and that IL-10-Ig significantly suppressed the expression of IL-17 as well as other proinflammatory cytokines, IL-1beta and TNF-alpha, in IL-1 stimulated splenocytes cultured from EAM rats
Murugaiyan et al., J Immunol 2008 (Encephalomyelitis, Autoimmune, Experimental...) : There was increased expression of Opn receptor on T cells, and Opn induced IL-17 production by CD4 ( + ) T cells via the beta ( 3 ) integrin receptor and Opn inhibited IL-10 production via the CD44 receptor
Eyerich et al., J Allergy Clin Immunol 2009 (Dermatitis, Atopic...) : In vivo, additional application of staphylococcal enterotoxin B induced IL-17 in APT reactions, whereas IL-4, IFN-gamma, and IL-10 were marginally regulated
Naundorf et al., Eur J Immunol 2009 : In contrast, IL-10 did not affect anti-CD3/anti-CD28 induced IL-17 production from memory T cells even in the presence of APC
Albright et al., Immunol Lett 2009 (Colitis) : Recombinant IL-10 suppressed and anti-IL-10 receptor antibody increased IFN-gamma, IL-17 and IL-12/IL-23 p40 production in bacterial lysate pulsed APC and plus CD4 ( + ) T cell co-cultures
Ramgolam et al., J Immunol 2009 (Multiple Sclerosis) : Studies of the mechanisms involved in the Th17 cell differentiation suggest that IFN-beta-1a inhibits IL-17 and induces IL-10 secretion via activated STAT1 and STAT3, respectively
Schaefer et al., J Leukoc Biol 2010 (Inflammation) : Culture of cIELs from IL-10 ( -/- ) mice with IL-23 resulted in an increase in ICOS and IL-17 expression, whereas IL-10 suppressed expression of ICOS and IL-17
Li et al., Immunol Cell Biol 2010 (Hepatitis B, Chronic) : Furthermore, endogenous IL-10 inhibited HBcAg stimulated production of IL-17A , IL-22, IL-6 and IL-23, but not TGF-ß
Liu et al., Rheumatology (Oxford) 2011 (Behcet Syndrome) : The inhibitory role of IFN-a on IL-17 was partly mediated by IL-10
Freches et al., Clinical and vaccine immunology : CVI 2011 (Tuberculosis) : Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated, Mycobacterium bovis BCG vaccinated mice
Wurbel et al., PloS one 2011 (Acute Disease...) : Upon re-stimulation, T cells isolated from these MLNs secrete significantly higher levels of TNFa, IFN?, IL2, IL-6 and IL-17A while down modulating IL-10 production
Brunsing et al., Immunology 2011 : Using ex vivo cultures of purified CD4 ( + ) T cells, we show that G-1 elicits IL-10 expression in T helper type 17 ( Th17 ) -polarized cells, increasing the number of IL-10 ( + ) and IL-10 ( + ) IL-17A ( + ) cells via de novo induction of IL-10
Galitovskiy et al., J Immunol 2011 (Colitis...) : Nicotine upregulated IL-10 and inhibited IL-17 production, which could be abolished by exogenous IL-12 that also abolished the nicotine dependent upregulation of regulatory T cells
Newcomb et al., J Immunol 2012 (Pneumonia...) : IL-13 regulates Th17 secretion of IL-17A in an IL-10 dependent manner ... In this study, we extend our in vitro findings and determine that IL-13 increases IL-10 production from Th17 polarized cells and that IL-13 induced IL-10 production negatively regulates the secretion of IL-17A and IL-21 ... To determine if IL-13 negatively regulates lung IL-17A expression via an IL-10 dependent mechanism in vivo, we used a model of respiratory syncytial virus ( RSV ) strain A2 infection in STAT1 knockout ( KO ) mice that increases lung IL-17A and IL-13 expression, cytokines not produced during RSV infection in wild-type mice
Perona-Wright et al., J Immunol 2012 (Schistosomiasis) : In this article, we demonstrate that schistosome-specific IL-17 induction by dendritic cells from low-pathology C57BL/6 mice is normally regulated by their concomitant induction of IL-10 ... Simultaneous stimulation of schistosome exposed C57BL/6 dendritic cells with a heat killed bacterium enabled these cells to overcome IL-10 regulation and induce IL-17 , even in wild-type C57BL/6 recipients
Tian et al., Invest Ophthalmol Vis Sci 2012 (Behcet Syndrome) : VitD3 was able to inhibit the gene expression of RORC, IL-17 , IL-23R, CCR6, and Th1 cell differentiation, but upregulated IL-10 expression
Pitt et al., J Immunol 2012 (Tuberculosis, Pulmonary) : In this study we show that inhibition of IL-10 signaling during BCG vaccination enhances host generated Ag-specific IFN-? and IL-17A responses, and that this regimen gives significantly greater protection against aerogenic M. tuberculosis challenge in both susceptible and relatively resistant strains of mice
Fitzgerald et al., J Immunol 2013 (Encephalomyelitis, Autoimmune, Experimental) : IFN-ß-driven IL-27 is responsible for the upregulation of IL-10, but not IL-17 suppression, by IFN-ß in human PBMCs. Surprisingly, IL-10 is not required for the suppression of IL-17 by either IL-27 or IFN-ß in this model or in de novo differentiating Th17 cells, nor is IL-27 signaling required for the suppression of experimental autoimmune encephalomyelitis ( EAE ) by IFN-ß in vivo
You et al., J Biol Regul Homeost Agents 2013 : The level of IL-10 produced by the treated cells was also enhanced , whereas the expression of IL-17 was prominently attenuated, which could be offset by anti-Jagged-1 antibody or DAPT
Gonzalez-Lombana et al., PLoS Pathog 2013 (Disease Models, Animal...) : Similarly, the production of IL-17 by cells from leishmaniasis patients was also regulated by IL-10 and IFN-?