Channavajhala et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Although KSR is a positive regulator of the Ras/mitogen activated protein ( MAP ) kinase pathway, the role of KSR in Cot mediated MAPK activation has not been identified
Gramling et al., Cell Death Differ 2012
(Cell Transformation, Neoplastic...) :
Therefore, loss of Ksr1 inhibits Ras/Mapk pathway signaling leading to increased Myc induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development
Joneson et al., J Biol Chem 1998
:
We examined the effect of mammalian KSR expression on the activation of extracellular ligand regulated ( ERK ) mitogen activated protein ( MAP ) kinase in fibroblasts