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EPHB2 — LIF

Text-mined interactions from Literome

Nagamoto-Combs et al., J Neurochem 1999 (Second Messenger Systems) : These results indicate that LIF mRNA levels can be regulated by ERK activation via stimulation of PKC in Schwann cells
Kodama et al., Am J Physiol Heart Circ Physiol 2000 (Cardiomegaly) : LIF sequentially activated Raf-1, MEK1/2, ERK1/2 , and p90 ( RSK )
Schuringa et al., Exp Cell Res 2002 (Teratocarcinoma) : In contrast, LIF does not activate STAT3, ERK , or the gp130 receptor in human N tera-2/D1 EC cells, although all receptor components are expressed
Nakao et al., Br J Pharmacol 2002 : 3 : Both PD98059 ( MAPK/ERK kinase inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated FCS induced LIF protein production and gene expression ... 5 : These findings demonstrate that both ERK and p38 MAPK are involved in FCS induced LIF secretion, whereas only p38 MAPK is important for IL-6 secretion, and that FCS induced activation of JNK has no effect on the production of LIF and IL-6
Chan et al., Blood 2003 : LIF stimulated phospho-Stat3 ( known to be critical for ES cell self-renewal and maintenance of an undifferentiated state ) and phospho-Erk levels were examined by immunoblotting
Kritikou et al., Development 2003 : Inhibition of LIF mediated ERK1/2 phosphorylation potentiates the proapoptotic effects of STAT3
Yanagisawa et al., Genes Cells 2004 : Disruption of lipid rafts by MBCD inhibited LIF induced ERK activation but not STAT3 activation
Yanagisawa et al., J Biochem 2005 (MAP Kinase Signaling System) : Leukemia inhibitory factor (LIF) induced ERK activation was also abolished in PDMP treated NECs, suggesting that PDMP specifically represses the Ras-MAPK pathway
Dekanty et al., J Biol Chem 2006 : However, LIF and PGF2alpha can trigger increases in ERK1/2 activity, which are required for their mitogenic responses because U0126, a MEK1/2 inhibitor, prevents both ERK1/2 activation and induction of DNA synthesis by LIF or PGF2alpha treatment
Mohri et al., J Biol Chem 2006 : Here we describe that leukemia inhibitory factor (LIF) , a member of IL-6 related cytokines, activated STAT3 and ERK1/2 in cardiac Sca-1+ stem cells
Levy et al., J Cell Biochem 2010 : Tumor necrosis factor alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells ... Our results show that TNFalpha was able to induce LIF transcription through ERK1/2 activation in a non-tumorigenic mouse mammary epithelial cell line, SCp2
Arthan et al., Cancer Lett 2010 (Carcinoma, Medullary...) : Ras/Raf/MEK/ERK activation was sufficient to induce growth inhibition and LIF expression in the human MTC line MZ-CRC-1
Prakash et al., Reprod Fertil Dev 2011 : Stimulation with LIF resulted in the activation of both signal transducer and activator of transcription ( STAT ) 3 Tyr ( 705 ) and ERK1/2 , but inhibition of ERK1/2 signalling by pretreatment of cells with U0126 ( 10 µM ) for 2h resulted in abrogation of LIF mediated increases in G ( 2 ) /M transition, with a significant decrease ( P < 0.05 ) in absolute cell numbers compared with control
Li et al., Protein Cell 2012 : We recently found that while LIF signaling augments ERK activity, BMP signaling inhibits ERK activity in mouse ES cells via direct upregulation of an ERK phosphatase-dual-specificity phosphatase 9