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AKT1 — PRKCZ
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
AKT1
—
PRKCZ
(physical association, affinity chromatography technology)
Doornbos et al., J Biol Chem 1999*
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IRef Hprd Interaction:
AKT1
—
PRKCZ
(in vitro)
Doornbos et al., J Biol Chem 1999*, Bourbon et al., J Biol Chem 2002*, Powell et al., Mol Cell Biol 2003*
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IRef Hprd Interaction:
AKT1
—
PRKCZ
(in vivo)
Doornbos et al., J Biol Chem 1999*, Bourbon et al., J Biol Chem 2002*, Powell et al., Mol Cell Biol 2003*
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IRef Innatedb Interaction:
Complex of 13 proteins
(unknown, -)
Paramio et al., Mol Cell Biol 2001*
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IRef Innatedb Interaction:
AKT1
—
PRKCZ
(unknown, -)
Wang et al., Cell Signal 2008*
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IRef Intact Interaction:
AKT1
—
PRKCZ
(physical association, anti bait coimmunoprecipitation)
Joshi et al., EMBO J 2008*
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IRef Intact Interaction:
AKT1
—
PRKCZ
(phosphorylation reaction, protein kinase assay)
Joshi et al., EMBO J 2008*
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IRef Ophid Interaction:
AKT1
—
PRKCZ
(aggregation, confirmational text mining)
Doornbos et al., J Biol Chem 1999*
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IRef Ophid Interaction:
AKT1
—
PRKCZ
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
STRING interaction:
AKT1
—
PRKCZ
(interaction, mapped from kegg_pathways)
-
STRING interaction:
AKT1
—
PRKCZ
(interaction, mapped from kegg_pathways)
-
STRING interaction:
PRKCZ
—
AKT1
(interaction, mapped from kegg_pathways)
-
STRING interaction:
PRKCZ
—
AKT1
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Martelli et al., Leukemia 2003
:
At variance with Ly294002, the
Akt inhibitor did not negatively
affect phosphorylation of
protein kinase C-zeta and it was less effective in downregulating p70S6 kinase (p70S6K) activity
Brubaker et al., Endocrinology 2004
:
The proliferative effects of GLP-1 appear to involve multiple intracellular pathways, including stimulation of
Akt ,
activation of
protein kinase Czeta , and transactivation of the epidermal growth factor receptor through the c-src kinase
Corbould et al., J Endocrinol 2007
(Insulin Resistance...) :
In the glucose metabolic pathway of insulin signaling, treatment of cells with T 10 nmol/l did not alter insulin stimulated phosphorylation of insulin receptor substrate-1 or
Akt , but insulin stimulated phosphorylation of
protein kinase C (PKC) zeta was
impaired