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PORCN — WNT3
Pathways - manually collected, often from reviews:
-
KEGG Wnt signaling pathway:
PORCN
→
WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B
(protein-protein, activation)
-
Reactome Reaction:
WNT3
→
PORCN
(reaction)
Hofmann et al., Trends Biochem Sci 2000*, Willert et al., Nature 2003*, Takada et al., Dev Cell 2006*, Komekado et al., Genes Cells 2007*, Ching et al., J Biol Chem 2008*, MacDonald et al., Dev Cell 2009, Biechele et al., Dev Biol 2011*, Barrott et al., Proc Natl Acad Sci U S A 2011*, Galli et al., PloS one 2011*, Herr et al., Dev Biol 2012, Janda et al., Science 2012, Najdi et al., Differentiation 2012*, Proffitt et al., J Biol Chem 2012*, van den Heuvel et al., EMBO J 1993*, Kadowaki et al., Genes Dev 1996*
Text-mined interactions from Literome
Wang et al., Nat Genet 2007
(Focal Dermal Hypoplasia) :
Mutations in X-linked
PORCN , a putative
regulator of
Wnt signaling, cause focal dermal hypoplasia
Grzeschik et al., Nat Genet 2007
(Focal Dermal Hypoplasia) :
Deficiency of
PORCN , a
regulator of
Wnt signaling, is associated with focal dermal hypoplasia
Biechele et al., Development 2013
(Wnt Signaling Pathway) :
Porcn dependent
Wnt signaling is not required prior to mouse gastrulation ... Our studies highlight the importance of Wnt3 and Wnt7b for embryonic and placental development but suggest that endogenous
Porcn dependent
Wnt secretion does not play an essential role in either implantation or blastocyst lineage specification