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ITGB1 — PTGS2
Text-mined interactions from Literome
Han et al., Int J Cancer 2005
(Carcinoma, Non-Small-Cell Lung...) :
Overall, these findings suggest that
COX-2 inhibitors
suppress alpha5beta1 integrin expression in NSCLC through effects on integrin alpha5 gene transcription mediated by Erk activation, increased Sp1, decreased AP-1 DNA binding and inactivation of SAPK/JNK signals
Boosani et al., Blood 2007
(Neoplasms...) :
We found that although both integrins were required for the inhibition of tube formation by alpha3 ( IV ) NC1 in endothelial cells, only
alpha3beta1 integrin was
sufficient to regulate
COX-2 in hypoxic endothelial cells
Hsu et al., Cell Signal 2007
:
At the mechanistic level,
anti-integrin beta1 and beta3 antibodies or beta1 and beta3 integrin small interference RNA
attenuated the US-induced
COX-2 expression
Liu et al., Molecular cancer 2010
(Chondrosarcoma) :
Cyclooxygenase-2 enhances
alpha2beta1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells