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ATF2 — EGF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ATF2 → EGF (increases) Olsen et al., Cell 2006*
  Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database

Text-mined interactions from Literome

Ouwens et al., EMBO J 2002 (MAP Kinase Signaling System) : Here, we show that in fibroblasts, insulin, epidermal growth factor (EGF) and serum activate ATF2 via a so far unknown two-step mechanism involving two distinct Ras effector pathways : the Raf-MEK-ERK pathway induces phosphorylation of ATF2 Thr71, whereas subsequent ATF2 Thr69 phosphorylation requires the Ral-RalGDS-Src-p38 pathway
He et al., Mol Carcinog 2008 (Cell Transformation, Neoplastic) : The K ( d ) value for EGCG binding to the Fyn SH2 domain was 0.367 +/- 0.122 microM and B ( max ) was 1.35 +/- 0.128 nmol/mg. Compared with control JB6 Cl41 cells, EGF induced phosphorylation of p38 MAP kinase (p38 MAPK) ( Thr180/Tyr182 ), ATF-2 ( Thr71 ) and signal transducer and activator of transcription 1 ( STAT1 ) ( Thr727 ) was decreased in siRNA-Fyn-JB6 cells