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CDKN1A — CSF2
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Comalada et al., Eur J Immunol 2004
:
Macrophage colony stimulating factor-, granulocyte-macrophage
colony stimulating factor- , or IL-3 dependent survival of macrophages, but not proliferation,
requires the expression of
p21 ( Waf1 ) through the phosphatidylinositol 3-kinase/Akt pathway
Huang et al., Neurosci Res 2007
(Disease Models, Animal...) :
In both N2a cells and in rat SCI model,
GM-CSF actually
reduced the expression of pro-apoptotic proteins ( p53,
p21 ( WAF1/CIP1 ) and Bax ), while further induced that of an anti-apoptotic protein ( Bcl-2 )
Stanley et al., Growth Factors 1989
:
Immune precipitation with the anti-Ha/Ki-ras p21 monoclonal antibody ( Y13-259 ) showed that expression of c-ras
p21 in CFC was
independent of
GM-CSF stimulation, but that phosphorylated c-ras p21 was present only after GM-CSF stimulation
Braun et al., Blood Cells Mol Dis 1998
:
We have previously reported
stimulation of
p21cip1/waf1 by steel factor and
GM-CSF in a factor dependent cell line and of p21cip1/waf1 involvement in hematopoiesis in vivo in p21cip1/waf1 gene knockout ( -/- ) mice