◀ Back to CSF2

CSF2 — CSF2RA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CSF2RA → Complex of CSF2-CSF2RA (increases, CSF2/CSF2RA Activity) Yokouchi et al., Oncogene 1999*
  Evidence: Here we report that APS was expressed in some human osteosarcoma cell lines, markedly so in SaOS-2 cells, and was tyrosine-phosphorylated in response to several growth factors, including platelet derived growth factor (PDGF), insulin-like growth factor (IGF), and granulocyte-macrophage colony stimulating factor (GM-CSF).
• KEGG Cytokine-cytokine receptor interaction: CSF2 → Complex of CSF2RA-CSF2RB (protein-protein, activation)
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → YWHAZ (YWHAZ) (modification, collaborate) Stomski et al., Blood 1999, Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
  Stomski et al., Blood 1999, Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: YWHAZ (YWHAZ) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
  Stomski et al., Blood 1999, Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) (modification, collaborate)
  Lilly et al., Blood 2001, Hansen et al., Cell 2008, Brizzi et al., J Biol Chem 1994, Quelle et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → STAT5 (STAT5A/STAT5B) (modification, activates) Lilly et al., Blood 2001, Piu et al., Oncogene 2002, Hansen et al., Cell 2008, Okuda et al., Blood 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → STAT5-active (STAT5A/STAT5B) (modification, activates)
  Lilly et al., Blood 2001, Piu et al., Oncogene 2002, Hansen et al., Cell 2008, Okuda et al., Blood 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: None → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) (modification, collaborate)
  Ramshaw et al., Blood 2007
  Evidence: mutant phenotype
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) → None (modification, activates) Ramshaw et al., Blood 2007
  Evidence: mutant phenotype
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB (dimer)/LYN/SYK complex (CSF2RB-LYN-SYK-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB (dimer)/LYN complex (CSF2RB-LYN-CSF2-CSF2RA) (modification, collaborate)
  Yousefi et al., J Exp Med 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB (dimer)/LYN/SYK complex (CSF2RB-LYN-SYK-CSF2-CSF2RA) → SYK (SYK) (modification, collaborate) Yousefi et al., J Exp Med 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB (dimer)/LYN complex (CSF2RB-LYN-CSF2-CSF2RA) → SYK (SYK) (modification, collaborate) Yousefi et al., J Exp Med 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha complex (CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB (dimer) complex (CSF2RB-CSF2-CSF2RA) (modification, collaborate)
  Sun et al., Blood 1999, Haman et al., J Biol Chem 1999*, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, McClure et al., Blood 2003*, Sakamaki et al., EMBO J 1992, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Hansen et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2008*, Woodcock et al., EMBO J 1994, Hercus et al., Blood 1994*, Lock et al., Proc Natl Acad Sci U S A 1994*, Woodcock et al., J Biol Chem 1996, Rajotte et al., J Exp Med 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha complex (CSF2-CSF2RA) → CSF2RB (dimer) complex (CSF2RB) (modification, collaborate)
  Sun et al., Blood 1999, Haman et al., J Biol Chem 1999*, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, McClure et al., Blood 2003*, Sakamaki et al., EMBO J 1992, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Hansen et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2008*, Woodcock et al., EMBO J 1994, Hercus et al., Blood 1994*, Lock et al., Proc Natl Acad Sci U S A 1994*, Woodcock et al., J Biol Chem 1996, Rajotte et al., J Exp Med 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB (dimer) complex (CSF2RB-CSF2-CSF2RA) → CSF2RB (dimer) complex (CSF2RB) (modification, collaborate)
  Sun et al., Blood 1999, Haman et al., J Biol Chem 1999*, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, McClure et al., Blood 2003*, Sakamaki et al., EMBO J 1992, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Hansen et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2008*, Woodcock et al., EMBO J 1994, Hercus et al., Blood 1994*, Lock et al., Proc Natl Acad Sci U S A 1994*, Woodcock et al., J Biol Chem 1996, Rajotte et al., J Exp Med 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) (modification, collaborate)
  Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Guthridge et al., EMBO J 2006, Dorsch et al., Biochem Biophys Res Commun 1994, Inhorn et al., Proc Natl Acad Sci U S A 1995, Lanfrancone et al., Oncogene 1995, Itoh et al., J Biol Chem 1996, Pratt et al., J Biol Chem 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) (modification, collaborate)
  Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: IKK beta (IKBKB) → GMCSF/GMR alpha/CSF2RB (dimer) complex (CSF2RB-CSF2-CSF2RA) (modification, collaborate)
  Ebner et al., Blood 2003
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: IKK beta (IKBKB) → GMCSF/GMR alpha/CSF2RB (dimer)/IKK beta complex (CSF2RB-IKBKB-CSF2-CSF2RA) (modification, collaborate)
  Ebner et al., Blood 2003
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB (dimer) complex (CSF2RB-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB (dimer)/IKK beta complex (CSF2RB-IKBKB-CSF2-CSF2RA) (modification, collaborate)
  Ebner et al., Blood 2003
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) (modification, collaborate)
  Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC/PI3K complex (CSF2RB-JAK2-YWHAZ-SHC1-PIK3CA-PIK3R1-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Guthridge et al., Blood 2004, Guthridge et al., EMBO J 2006, Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → None (modification, activates) Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1) → None (modification, activates) Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → STAT1-3-active (STAT1/STAT3) (modification, activates)
  Piu et al., Oncogene 2002, Brizzi et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → STAT1-3 (STAT1/STAT3) (modification, activates) Piu et al., Oncogene 2002, Brizzi et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → GMCSF/GMR alpha complex (CSF2-CSF2RA) (modification, collaborate)
  Sun et al., Blood 1999, Haman et al., J Biol Chem 1999*, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, Lilly et al., Blood 2001, McClure et al., Blood 2003*, Sakamaki et al., EMBO J 1992, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Hansen et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2008*, Brizzi et al., J Biol Chem 1994, Woodcock et al., EMBO J 1994, Quelle et al., Mol Cell Biol 1994, Hercus et al., Blood 1994*, Lock et al., Proc Natl Acad Sci U S A 1994*, Woodcock et al., J Biol Chem 1996, Rajotte et al., J Exp Med 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2) (modification, collaborate)
  Sun et al., Blood 1999, Haman et al., J Biol Chem 1999*, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, Lilly et al., Blood 2001, McClure et al., Blood 2003*, Sakamaki et al., EMBO J 1992, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Hansen et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2008*, Brizzi et al., J Biol Chem 1994, Woodcock et al., EMBO J 1994, Quelle et al., Mol Cell Biol 1994, Hercus et al., Blood 1994*, Lock et al., Proc Natl Acad Sci U S A 1994*, Woodcock et al., J Biol Chem 1996, Rajotte et al., J Exp Med 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha complex (CSF2-CSF2RA) → CSF2RB/JAK2 (dimer) complex (CSF2RB-JAK2) (modification, collaborate)
  Sun et al., Blood 1999, Haman et al., J Biol Chem 1999*, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, Lilly et al., Blood 2001, McClure et al., Blood 2003*, Sakamaki et al., EMBO J 1992, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Hansen et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2008*, Brizzi et al., J Biol Chem 1994, Woodcock et al., EMBO J 1994, Quelle et al., Mol Cell Biol 1994, Hercus et al., Blood 1994*, Lock et al., Proc Natl Acad Sci U S A 1994*, Woodcock et al., J Biol Chem 1996, Rajotte et al., J Exp Med 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: SHP2 (PTPN11) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) (modification, collaborate)
  Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: SHP2 (PTPN11) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHP2 complex (CSF2RB-JAK2-PTPN11-CSF2-CSF2RA) (modification, collaborate)
  Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHP2 complex (CSF2RB-JAK2-PTPN11-CSF2-CSF2RA) (modification, collaborate)
  Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database GMCSF-mediated signaling events: GRB2/GAB2 complex (GRB2-GAB2) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000
  Evidence: mutant phenotype
• NCI Pathway Database Alpha9 beta1 integrin signaling events: GMCSF/GMR alpha complex (CSF2-CSF2RA) → alpha9/beta1 Integrin/GMCSF/GMR alpha complex (ITGA9-ITGB1-CSF2-CSF2RA) (modification, collaborate)
  Chen et al., Immunity 2006*
  Evidence: physical interaction
• NCI Pathway Database Alpha9 beta1 integrin signaling events: GMCSF/GMR alpha complex (CSF2-CSF2RA) → alpha9/beta1 Integrin complex (ITGA9-ITGB1) (modification, collaborate)
  Chen et al., Immunity 2006*
  Evidence: physical interaction
• NCI Pathway Database Alpha9 beta1 integrin signaling events: alpha9/beta1 Integrin/GMCSF/GMR alpha complex (ITGA9-ITGB1-CSF2-CSF2RA) → alpha9/beta1 Integrin complex (ITGA9-ITGB1) (modification, collaborate)
  Chen et al., Immunity 2006*
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha complex (CSF2-CSF2RA) → GMR alpha (CSF2RA) (modification, collaborate) Haman et al., J Biol Chem 1999*, Lopez et al., EMBO J 1992*, Hayashida et al., Proc Natl Acad Sci U S A 1990*, Kanakura et al., Blood 1991*, Shanafelt et al., J Biol Chem 1991*, Bussolino et al., Nature 1989*, Gearing et al., EMBO J 1989*, Walker et al., EMBO J 1985*, Park et al., J Exp Med 1986*, Woodcock et al., EMBO J 1994, Hercus et al., Blood 1994*, Rajotte et al., J Exp Med 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha complex (CSF2-CSF2RA) → GMCSF (CSF2) (modification, collaborate) Haman et al., J Biol Chem 1999*, Lopez et al., EMBO J 1992*, Hayashida et al., Proc Natl Acad Sci U S A 1990*, Kanakura et al., Blood 1991*, Shanafelt et al., J Biol Chem 1991*, Bussolino et al., Nature 1989*, Gearing et al., EMBO J 1989*, Walker et al., EMBO J 1985*, Park et al., J Exp Med 1986*, Woodcock et al., EMBO J 1994, Hercus et al., Blood 1994*, Rajotte et al., J Exp Med 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMR alpha (CSF2RA) → GMCSF (CSF2) (modification, collaborate) Haman et al., J Biol Chem 1999*, Lopez et al., EMBO J 1992*, Hayashida et al., Proc Natl Acad Sci U S A 1990*, Kanakura et al., Blood 1991*, Shanafelt et al., J Biol Chem 1991*, Bussolino et al., Nature 1989*, Gearing et al., EMBO J 1989*, Walker et al., EMBO J 1985*, Park et al., J Exp Med 1986*, Woodcock et al., EMBO J 1994, Hercus et al., Blood 1994*, Rajotte et al., J Exp Med 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB (dimer)/LYN complex (CSF2RB-LYN-CSF2-CSF2RA) → LYN (LYN) (modification, collaborate) Adachi et al., J Immunol 1999, Dahl et al., Genes Cells 2000*, Perugini et al., Blood 2010*, Li et al., J Immunol 1995, Corey et al., EMBO J 1993*, Yousefi et al., J Exp Med 1996, Wei et al., J Immunol 1996*, Adachi et al., J Immunol 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB (dimer)/LYN complex (CSF2RB-LYN-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB (dimer) complex (CSF2RB-CSF2-CSF2RA) (modification, collaborate)
  Adachi et al., J Immunol 1999, Dahl et al., Genes Cells 2000*, Perugini et al., Blood 2010*, Li et al., J Immunol 1995, Corey et al., EMBO J 1993*, Yousefi et al., J Exp Med 1996, Wei et al., J Immunol 1996*, Adachi et al., J Immunol 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: LYN (LYN) → GMCSF/GMR alpha/CSF2RB (dimer) complex (CSF2RB-CSF2-CSF2RA) (modification, collaborate)
  Adachi et al., J Immunol 1999, Dahl et al., Genes Cells 2000*, Perugini et al., Blood 2010*, Li et al., J Immunol 1995, Corey et al., EMBO J 1993*, Yousefi et al., J Exp Med 1996, Wei et al., J Immunol 1996*, Adachi et al., J Immunol 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → SHC (SHC1) (modification, collaborate) Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ/SHC complex (CSF2RB-JAK2-YWHAZ-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
  Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: SHC (SHC1) → GMCSF/GMR alpha/CSF2RB/JAK2 (dimer)/YWHAZ complex (CSF2RB-JAK2-YWHAZ-CSF2-CSF2RA) (modification, collaborate)
  Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) (modification, collaborate)
  Ramshaw et al., Blood 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA) → SHIP (INPP5D) (modification, collaborate) Ramshaw et al., Blood 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-CSF2-CSF2RA) → SHIP (INPP5D) (modification, collaborate) Ramshaw et al., Blood 2007
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: CSF2 → CSF2RA (direct_complex) Gearing et al., EMBO J 1989*
• Reactome Reaction: CSF2 → CSF2RA (reaction) Sakamaki et al., EMBO J 1992, Duronio et al., J Biol Chem 1992, Gearing et al., EMBO J 1989*, Sorensen et al., J Biol Chem 1989, Quelle et al., Mol Cell Biol 1994, Feng et al., Mol Cell Biol 1997, Bone et al., J Biol Chem 1997, Flores-Morales et al., Mol Cell Endocrinol 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CSF2 — CSF2RA (direct interaction, pull down) Woodcock et al., EMBO J 1994
• IRef Dip Interaction: CSF2 — CSF2RA (physical association, biochemical) Woodcock et al., EMBO J 1994
• IRef Dip Interaction: CSF2 — CSF2RA (physical association, experimental interaction detection) Gearing et al., EMBO J 1989*
• IRef Dip Interaction: CSF2 — CSF2RA (physical association, experimental interaction detection) Woodcock et al., EMBO J 1994
• IRef Hprd Interaction: CSF2 — CSF2RA (in vivo) Niu et al., Blood 1999*, Hayashida et al., Proc Natl Acad Sci U S A 1990*, Lia et al., J Biol Chem 1996*, Matsuguchi et al., J Biol Chem 1997*
• IRef Hprd Interaction: CSF2 — CSF2RA (in vitro) Niu et al., Blood 1999*, Hayashida et al., Proc Natl Acad Sci U S A 1990*, Lia et al., J Biol Chem 1996*, Matsuguchi et al., J Biol Chem 1997*
• IRef Intact Interaction: Complex of CSF2-CSF2RA-CSF2RB (physical association, x-ray crystallography) Hansen et al., Cell 2008
• IRef Ophid Interaction: CSF2 — CSF2RA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Okuda et al., Ann N Y Acad Sci 1999 : Binding of GM-CSF activates at least one receptor associated tyrosine kinase, JAK2, and rapidly induces tyrosine phosphorylation of the GMR beta c chain ( GMR beta ), but not the GMR alpha chain ( GMR alpha )
Prevost et al., Cytokine 2000 : The GM-CSF receptor consists of a GM-CSF specific low affinity alpha-subunit ( GMRalpha ) and a beta-subunit ( betac ) that associates with GMRalpha in the presence of GM-CSF to form a high-affinity complex
Mirza et al., Biochem J 2010 : The results indicate a previously unrecognized role for the Ig-like domain, and in particular Cys60, of GM-CSFRalpha in the binding of GM-CSF and subsequent activation of cellular signalling
Jubinsky et al., Blood 1994 (Leukemia) : Anti-GMR alpha inhibited the GM-CSF dependent growth of cell lines and normal bone marrow cells and inhibited the binding of iodinated GM-CSF to its receptor
Okuda et al., Blood 1997 : Binding of GM-CSF activates at least one receptor associated tyrosine kinase, JAK2, and rapidly induces tyrosine phosphorylation of the GMR betac-chain ( GMRbeta ), but not the GMR alpha-chain (GMRalpha)