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IL4 — MUC15
Text-mined interactions from Literome
Dabbagh et al., J Immunol 1999
(Metaplasia) :
IL-4 induces
mucin gene expression and goblet cell metaplasia in vitro and in vivo ... In this study we hypothesized that
IL-4 induces airway epithelial cell
mucin gene expression and mucous glycoconjugate production by direct action on these cells
Seong et al., Acta Otolaryngol 2002
(Chronic Disease...) :
Among inflammatory mediators,
IL-4 is
responsible for the decrease in MUC5AC mRNA and MUC5AC
mucin secretion
Hauber et al., Laryngoscope 2008
(Hypersensitivity...) :
IL-4 , IL-9, and IL-13 significantly
increased epithelial mucin expression ( P < .05 ). Dexamethasone reduced Th2 type cytokine induced mucin expression in a dose dependent manner being statistically significant at concentrations > or=4.0 micromol/L ( IL-4 ) and > or=40.0 micromol/L ( IL-9 and IL-13 ) ( P < .05 ). ACC had no significant effect on IL-4 and IL-13 induced mucin expression, whereas IL-9 induced mucin expression was significantly decreased at concentrations > or=3.0 mmol/L ( P < .05 ). NFA and MSI-2216 decreased Th2 type cytokine induced
mucin expression in a dose dependent manner. This effect was statistically significant at concentrations > or=100 micromol/L ( NFA ) and > or=50 micromol/L ( MSI-2216 ) ( P < .05 )
Lee et al., J Parasitol 2010
:
We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and
MUC expression is
regulated by interferon (IFN)-gamma,
interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen ... We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and
MUC expression is
regulated by interferon (IFN)-gamma,
interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Kim et al., J Immunol 2010
:
T cell Ig domain and
mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation
enhances IL-4 production but inhibits IFN-gamma production
Temann et al., Am J Respir Cell Mol Biol 1997
:
Thus, transgenic mice that overexpress murine IL-4 selectively within the lung were used to study the
effect of
IL-4 on mucus glycoprotein gene expression and
mucin release