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ANGPT2 — CTGF

Text-mined interactions from Literome

Rupérez et al., Circulation 2003 (Fibrosis) : Our results show that Ang II , via AT1, increases CTGF in vascular cells both in vivo and in vitro
Long et al., Zhonghua Jie He He Hu Xi Za Zhi 2007 (Pulmonary Fibrosis) : Ang II promoted HLF cell transdifferentiation into myofibroblasts and increased collagen production through induction of CTGF expression
Che et al., Hypertens Res 2008 : The results demonstrated that, in cultured AFs, Ang II increased CTGF production via AT(1)-R, which could be mediators of collagen synthesis by Ang II
Yang et al., Hypertension 2009 (Disease Models, Animal...) : Additional studies revealed that, in addition to a late ( 24-hour ) TGF-beta dependent Smad2/3 activation, Ang II also induced a rapid activation of Smad2/3 at 15 minutes and expression of CTGF and collagen I in tubular epithelial cells lacking the TGF-beta gene, which was blocked by the addition of an Ang II type 1 receptor antagonist ( losartan ) and inhibitors to extracellular signal regulated kinase 1/2 ( PD98059 ) and p38 ( SB203580 ) but not by inhibitors to Ang II type 2 receptor ( PD123319 ) or c-Jun N-terminal kinase ( SP600125 ), demonstrating a TGF-beta independent, Ang II type 1 receptor mediated extracellular signal regulated kinase/p38 mitogen activated protein kinase cross-talk pathway in Ang II-mediated CTGF and collagen I expression ... In conclusion, Ang II induces tubular CTGF expression and renal fibrosis via the TGF-beta dependent and -independent Smad3 signaling pathways, suggesting that targeting Smad3 may have therapeutic potential for hypertensive nephropathy
Tung et al., Toxicol In Vitro 2010 : Angiotensin (ANG) II may induce CTGF expression in the heart and kidney and plays an important role in the pathogenesis of lung fibrosis
Ko et al., Circ J 2011 (Atrial Fibrillation...) : In perfused rat hearts, Ang II stimulation increased CTGF expression, which could be inhibited by Ang II type I receptor antagonist
Morales et al., Int J Biochem Cell Biol 2012 (Fibrosis) : In this paper, we show that in myoblasts, Ang-II induced the increase of transforming growth factor beta 1 ( TGF-ß1 ) and connective tissue growth factor (CTGF) expression through its AT-1 receptor ... However, only the p38MAPK activity was critical for the Ang-II induced fibrotic effects, as indicated by the decrease in the Ang-II induced TGF-ß1 and CTGF expression and fibronectin levels by SB-203580, an inhibitor of the p38MAPK, but not by U0126, an inhibitor of ERK1/2 phosphorylation