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CREB5 — PTH

Text-mined interactions from Literome

Tyson et al., Endocrinology 1999 : PTH induces c-fos expression rapidly and transiently in osteoblastic cells and requires the activity of the cAMP response element binding protein ( CREB ) ... PTH increases the level of phosphorylation of CREB at S133 in a time- and dose dependent manner, correlating with the time and level of activation of PKA in response to PTH ... PTH- ( 1-34 ) and - ( 1-31 ), each known to activate the cAMP pathway, induced the phosphorylation of CREB and increased the levels of c-fos messenger RNA, whereas PTH- ( 3-34 ), - ( 13-34 ), and - ( 28-48 ) could not ... Specific inhibitors of calcium/calmodulin dependent protein kinases and protein kinase C could not inhibit CREB phosphorylation or c-fos expression in response to PTH ; however, H-89, a specific inhibitor of PKA, could do so in a dose dependent manner
Tyson et al., Endocrinology 2002 : We have previously shown that PTH induction of c-fos expression in the rat osteoblastic cell line UMR 106-01 requires the phosphorylation of cAMP response element binding protein ( CREB ) at serine 133 ... We propose that GSK-3beta phosphorylates CREB at serine 129 and thus is required for the increased transcriptional activity of CREB in response to PTH
Chen et al., Am J Physiol Cell Physiol 2002 (Osteosarcoma) : Consistent with the role for cAMP/PKA signaling in this response, PTH induces transient cAMP elevation, PKA activation, and cAMP-responsive element binding protein ( CREB ) phosphorylation
Schnoke et al., J Orthop Res 2007 : Some signaling molecules like the extracellular response kinases 1/2 ( Erk1/2 ) and the cAMP response element binding protein ( CREB ) were activated by insulin and PTH , respectively, but not by PEMF treatment
Sabbieti et al., J Cell Physiol 2009 : Western blot time course studies showed that PTH increased phospho-CREB within 15 min that was sustained for 24 h in Fgf2+/+ but had no effect in Fgf2-/- osteoblasts
Huang et al., J Bone Miner Res 2010 : On electrophoretic mobility shift analysis, PTH stimulated binding of phosphorylated CREB to an oligonucleotide spanning the CRE and binding of NFATc1, c-Fos, and c-Jun to an oligonucleotide spanning the NFAT/AP-1 composite site
Yuan et al., J Bone Miner Res 2011 (Hypophosphatemia, Familial) : PTH treatment similarly induced cAMP accumulation and phosphorylation of ERK1/2 and CREB in the osteoblasts from each genotype
Zhang et al., PloS one 2011 : To test this hypothesis, we first demonstrated that PTH signaling activated CREB by phosphorylation in osteoblasts, and that both PTH and CREB were capable of promoting osteoblastic differentiation of primary mouse osteoblast cells and multiple rodent osteoblast cell lines ... Together, these results demonstrate that the anabolic function of PTH signaling in bone is mediated , at least in part, by CREB transactivation of BMP2 expression in osteoblasts