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PDGFRB — PTPN11

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PTPN11 → PDGFRB (directlyIncreases, PTPN11 Activity)
  Evidence: from http://harvester.embl.de/harvester/P096/P09619.htm phosphorylates tyr residues at the c-terminus of ptpn11
• NCI Pathway Database PDGFR-beta signaling pathway: None → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database PDGFR-beta signaling pathway: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) → None (modification, activates) Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: GRB2/SOS1 complex (GRB2-SOS1) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database SHP2 signaling: None → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database SHP2 signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) → None (modification, activates) Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → SHP2 (PTPN11) (modification, collaborate) Rönnstrand et al., Oncogene 1999, Ekman et al., Oncogene 2002, Li et al., Mol Cell Biol 1994, Roche et al., EMBO J 1996
  Evidence: assay, physical interaction
• NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Ekman et al., Oncogene 2002, Li et al., Mol Cell Biol 1994, Roche et al., EMBO J 1996
  Evidence: assay, physical interaction
• NCI Pathway Database SHP2 signaling: SHP2 (PTPN11) → PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Ekman et al., Oncogene 2002, Li et al., Mol Cell Biol 1994, Roche et al., EMBO J 1996
  Evidence: assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → SHP2 (PTPN11) (modification, collaborate) Rönnstrand et al., Oncogene 1999, Ekman et al., Oncogene 2002, Li et al., Mol Cell Biol 1994, Roche et al., EMBO J 1996
  Evidence: assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Ekman et al., Oncogene 2002, Li et al., Mol Cell Biol 1994, Roche et al., EMBO J 1996
  Evidence: assay, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: SHP2 (PTPN11) → PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Ekman et al., Oncogene 2002, Li et al., Mol Cell Biol 1994, Roche et al., EMBO J 1996
  Evidence: assay, physical interaction
• NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database SHP2 signaling: GRB2/SOS1 complex (GRB2-SOS1) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
  Li et al., Mol Cell Biol 1994
  Evidence: physical interaction
• NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → PAG1 (PAG1) (modification, activates) Zhang et al., Mol Cell 2004
  Evidence: assay
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → PAG1 (PAG1) (modification, activates) Zhang et al., Mol Cell 2004
  Evidence: assay
• Reactome Reaction: PDGFRB → PTPN11 (reaction) Lechleider et al., J Biol Chem 1993*, Heldin et al., Biochim Biophys Acta 1998
• Reactome Reaction: PDGFRB → PTPN11 (indirect_complex) Lechleider et al., J Biol Chem 1993*, Heldin et al., Biochim Biophys Acta 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PTPN11 — PDGFRB Roche et al., EMBO J 1996
• IRef Bind Interaction: PTPN11 — PDGFRB Kazlauskas et al., Proc Natl Acad Sci U S A 1993*
• IRef Bind_translation Interaction: PTPN11 — PDGFRB (affinity chromatography technology) Roche et al., EMBO J 1996
• IRef Bind_translation Interaction: PTPN11 — PDGFRB (coimmunoprecipitation) Kazlauskas et al., Proc Natl Acad Sci U S A 1993*
• IRef Biogrid Interaction: PTPN11 — PDGFRB (direct interaction, two hybrid) Keilhack et al., J Cell Biol 2001*
• IRef Biogrid Interaction: PTPN11 — PDGFRB (direct interaction, pull down) Lechleider et al., J Biol Chem 1993*
• IRef Hprd Interaction: PTPN11 — PDGFRB (in vitro) Lin et al., FEBS Lett 2003*, Lechleider et al., J Biol Chem 1993*, Bennett et al., Proc Natl Acad Sci U S A 1994*
• IRef Hprd Interaction: PTPN11 — PDGFRB (in vivo) Lin et al., FEBS Lett 2003*, Lechleider et al., J Biol Chem 1993*, Bennett et al., Proc Natl Acad Sci U S A 1994*
• IRef Intact Interaction: PDGFRB — PTPN11 (physical association, anti tag coimmunoprecipitation) Markova et al., Biochemistry 2003*
• IRef Intact Interaction: PDGFRB — PTPN11 (physical association, affinity technology) Markova et al., Biochemistry 2003*
• IRef Intact Interaction: PDGFRB — PTPN11 (physical association, proximity ligation assay) Liu et al., Mol Cell Proteomics 2013
• IRef Intact Interaction: PDGFRB — PTPN11 (association, x-ray crystallography) Eck et al., Nature 1996*
• IRef Intact Interaction: PDGFRB — PTPN11 (association, surface plasmon resonance) Huyer et al., Biochemistry 1995*
• IRef Intact Interaction: PDGFRB — PTPN11 (association, unspecified method) Kazlauskas et al., Proc Natl Acad Sci U S A 1993*
• IRef Intact Interaction: PDGFRB — PTPN11 (association, enzymatic study) Dechert et al., J Biol Chem 1994*
• IRef Intact Interaction: PDGFRB — PTPN11 (association, experimental interaction detection) Feng et al., Oncogene 1994*
• IRef Ophid Interaction: PDGFRB — PTPN11 (aggregation, confirmational text mining) Lechleider et al., J Biol Chem 1993*
• IRef Ophid Interaction: PDGFRB — PTPN11 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Meng et al., Mol Cell 2002 : Our results indicate that SHP-2 inhibits PDGFR signaling and suggest a mechanism by which autophosphorylation of the PDGFR occurs despite its association with SHP-2
Newton et al., J Biol Chem 2005 : Using a panel of cytoplasmic domain mutants of the chimeric M-CSF/PDGFR-beta, we confirmed that the kinase domain of PDGFR-beta is absolutely required for LRP tyrosine phosphorylation but that PDGFR-beta mediated activation of phosphatidylinositol 3-kinase, RasGAP, SHP-2 , phospholipase C-gamma, and Src are not necessary for LRP tyrosine phosphorylation
Kiyan et al., Exp Cell Res 2009 : Active PDGFR-beta was required for the uPA induced SHP-2 phosphorylation
Lu et al., Oncogene 1998 : These observations indicate that Shp-2 not only participates in transmission of signals from growth factor receptors but also plays a specific role in the control of the PDGFR-beta expression