◀ Back to ESR2
ESR2 — NCOA2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
NCOA2
—
ESR2
(direct interaction, fluorescent resonance energy transfer)
Iannone et al., Cytometry 2001
-
IRef Biogrid Interaction:
NCOA2
—
ESR2
(direct interaction, two hybrid)
Kraichely et al., Endocrinology 2000*
-
IRef Biogrid Interaction:
NCOA2
—
ESR2
(direct interaction, two hybrid)
Monroe et al., J Endocrinol 2003*
-
IRef Biogrid Interaction:
NCOA2
—
ESR2
(direct interaction, unspecified method)
Bramlett et al., Mol Endocrinol 2001*
-
IRef Biogrid Interaction:
NCOA2
—
ESR2
(direct interaction, fluorescent resonance energy transfer)
Bai et al., Mol Endocrinol 2003*
-
IRef Biogrid Interaction:
NCOA2
—
ESR2
(direct interaction, pull down)
Kraichely et al., Endocrinology 2000*
Text-mined interactions from Literome
Labrie et al., J Steroid Biochem Mol Biol 1999
(Breast Neoplasms...) :
Most importantly, the antiestrogen hydroxytamoxifen has no inhibitory effect on the
SRC-1 induced
ER beta activity while the pure antiestrogen EM-652 completely abolishes this effect, thus strengthening the need to use pure antiestrogens in breast cancer therapy in order to control all known aspects of ER-regulated gene expression
Hartmaier et al., Mol Endocrinol 2012
(Bone Demineralization, Pathologic...) :
The coregulator steroid receptor coactivator
(SRC)-1 increases transcriptional activity of the
estrogen receptor ( ER ) in a number of tissues including bone
Tremblay et al., Mol Endocrinol 1997
:
Moreover, the ligand independent stimulatory
effect of
SRC-1 on
ER beta transcriptional activity is abolished by ICI 182,780, but not by OHT