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IL6 — TGFB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Eickelberg et al., J Biol Chem 1999
:
Transforming growth factor-beta1 induces
interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts ... Transient transfections of fibroblasts with a luciferase reporter gene construct containing nucleotides -651 to +1 of the human IL-6 promoter revealed that
TGF-beta1 also potently
activated IL-6 promoter activity ... Our data thus demonstrate that
TGF-beta1 is a potent
inducer of
IL-6 in primary human lung fibroblasts
Linker-Israeli et al., Clin Immunol 1999
(Lupus Erythematosus, Systemic) :
We found that ( 1 ) exogenous rIL-10 and rIL-4 mediated reduction of constitutive and lectin induced IL-6 in monocytes of SLE patients as effectively as that of controls ; ( 2 ) IL-6 mRNA decay was significantly delayed in SLE with active disease ( P < 0.001 ) ; ( 3 ) adding rIL-10 or neutralizing endogenous IL-1 beta and TNF-alpha down-regulated IL-6 mainly by destabilizing IL-6 transcripts, whereas exogenous IL-4 and
TGF beta 1 down-regulated
IL-6 transcriptionally ; ( 4 ) time kinetics and levels of IL-10 were lower than those of IL-6 and IL-1 beta
Sayah et al., J Neurochem 1999
(Astrocytoma) :
Whereas IL-1beta, tumor necrosis factor-alpha, and
transforming growth factor-beta mRNA levels remained unchanged, stimulation of astrocytoma cells ( T98G, CB193, U118MG ) by C3a, C5a, and peptidic C3aR and C5aR agonists
induced an increase in the
IL-6 mRNA level
Chen et al., J Biol Chem 1999
(Carcinoma, Hepatocellular...) :
Interleukin-6 inhibits
transforming growth factor-beta induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
Fujisawa et al., Placenta 2000
(Choriocarcinoma...) :
IL-6 transcription and secretion were dose-dependently
enhanced by stimulation with IL-1beta, tumour necrosis factor (TNF)-alpha,
transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate ( TPA )
Junn et al., J Immunol 2000
:
Antioxidants including NAC, glutathione, and catalase reduced
TGF-beta1 induced
IL-6 gene expression, and direct H2O2 treatment induced IL-6 expression in a dose dependent manner ... In addition, TGF-beta1 or H2O2 increased MAPK activity which was reduced by EGTA and NAC, suggesting that MAPK is involved in
TGF-beta1 induced
IL-6 expression
Gerber et al., J Interferon Cytokine Res 2001
:
The proinflammatory cytokine
IL-6 induced an upregulation of cathepsin L, whereas
TGF-beta 1 suppressed cathepsin B and L expression
Vermes et al., J Bone Joint Surg Am 2001
(Osteolysis) :
Exogenous tumor necrosis factor-alpha also
enhanced the release of
interleukin-6 ( p < 0.01 ) and transforming growth factor-beta1 ( p < 0.05 ), whereas the secretion of
transforming growth factor-beta1 was increased by insulin-like growth factor-I and prostaglandin E2 as well
Lyons et al., Infect Immun 2001
(Chronic Disease...) :
Immunological studies of chronic ocular toxoplasmosis : up-regulation of major histocompatibility complex class I and
transforming growth factor beta and a protective
role for
interleukin-6
Baroni et al., Arch Dermatol Res 2001
:
Moreover, we demonstrated that M. furfur modulates proinflammatory and immunomodulatory cytokine synthesis by downregulating IL-1alpha and by
inhibiting IL-6 and TNF-alpha and by upregulating IL-10 and
TGF-beta1
Basu et al., Glia 2002
(Brain Injuries...) :
TGFbeta1 blocked the induction of the tyrosine kinases, Cox-2, and the induction of
IL-6 and TNFalpha mRNAs
Haller et al., J Biol Chem 2003
(Bacteroides Infections) :
Interestingly,
TGF-beta1 inhibited B. vulgatus- and lipopolysaccharide (LPS) induced NF-kappaB transcriptional activity as well as
interleukin-6 (IL-6) mRNA accumulation and protein secretion in IEC ... Moreover, the specific histone deacetylase inhibitor trichostatin A blocked B. vulgatus/LPS induced histone acetylation/phosphorylation ( Lys-9/Ser-10 ) and reversed
TGF-beta1 mediated inhibition of
IL-6 gene expression
Park et al., Oncogene 2003
(Prostatic Neoplasms) :
Transforming growth factor-beta1 activates
interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways ... Here, we show that
TGF-beta1 activates
interleukin (IL)-6 , which has been implicated in the malignant progression of prostate cancers, via multiple signaling pathways including Smad2, nuclear factor-kappaB (NF-kappaB), JNK, and Ras ...
TGF-beta1 induced
IL-6 gene expression was strongly inhibited by DN-Smad2 but not by DN-Smad3 while it was further activated by wild-type Smad2 transfection ...
IL-6 activation by
TGF-beta1 was accompanied by nuclear translocation of NF-kappaB, which was blocked by the p38 inhibitors SB202190 and SB203580 or by IkappaBalphaDeltaN transfection, indicating the crucial role for the p38-NF-kappaB signaling in TGF-beta1 induction of IL-6 ... TGF-beta1 activated c-Jun phosphorylation, and
IL-6 induction by
TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6 ... It was also found that the Ras-Raf-MEK1 cascade is activated by TGF-beta1 and participates in the
TGF-beta1 induction of
IL-6 in an AP-1 dependent manner ... In addition, a time course IL-6 decay revealed that mRNA stability of IL-6 is modestly increased by TGF-beta1, indicating that
TGF-beta1 also
regulates IL-6 at the post-transcriptional level ... Collectively, our data demonstrate that
IL-6 expression is
stimulated by tumor producing
TGF-beta1 in human prostate cancer cells through multiple signaling pathways including Smad2, p38, JNK, and Ras, and enhanced expression of IL-6 could contribute to the oncogenic switch of TGF-beta1 role for prostate tumorigenesis, in part by counteracting its growth suppression function
Penkowa et al., J Neurosci Res 2003
(Disease Models, Animal...) :
Also,
IL-6 induced significant
increases in proinflammatory cytokines IL-1, IL-12, and tumor necrosis factor-alpha as well as growth factors basic fibroblast growth factor (bFGF),
transforming growth factor-beta , neurotrophin-3, angiopoietin, vascular endothelial growth factor, and the receptor for bFGF
McGee et al., Immunology 1992
:
Using the IEC-6 rat intestinal epithelial cell line as a model system,
TGF-beta 1 was found to
enhance interleukin-6 (IL-6) secretion by the IEC-6 cells
Bry et al., Am J Obstet Gynecol 1992
(Obstetric Labor, Premature) :
Human amnion cells in monolayer culture were treated with
interleukin-1 , tumor necrosis factor, or vehicle in the
presence or absence of
transforming growth factor-beta
Walia et al., FASEB J 2003
:
In conclusion, we show that : 1 ) TGF-beta receptor Type II is predominantly located on basolateral membrane and receptor stimulation activates Smad pathway ; 2 )
TGF-beta1 down-regulates IL-6 induced tyrosine phoshorylation of STAT1 and STAT3 and ICAM-1 expression ; and 3 ) Smad2 is
required for the down-regulation of
IL-6 signaling by TGF-beta
Feinberg et al., J Biol Chem 2004
(Arteriosclerosis...) :
Conversely,
TGF-beta1 inhibition of cytokine mediated induction of iNOS and
IL-6 expression was completely blocked in Smad3-deficient VSMCs
Perrier d'Hauterive et al., Journal de gynécologie, obstétrique et biologie de la reproduction 2004
:
The molecular basis of the implantation window remains to be defined In the present study, we investigated the
role of hCG,
TGFbeta1 , IGF1 and IGF2 in the secretion of leukemia inhibitory factor (LIF) and
interleukin-6 (IL-6) by human epithelial endometrial cells in culture
Perrier d'Hauterive et al., Hum Reprod 2004
:
Transforming growth factor beta1 stimulated LIF and reduced
IL-6 secretion
Zhang et al., J Biol Chem 2005
:
Interleukin-6 regulation of transforming growth factor ( TGF ) -beta receptor compartmentalization and turnover
enhances TGF-beta1 signaling ... We have assessed the
effect of
IL-6 on
TGF-beta1 signaling and defined the mechanism by which this occurred ... These results indicate that
IL-6 increased trafficking of TGF-beta1 receptors to non-lipid raft associated pools results in augmented
TGF-beta1 Smad signaling
Méndez-Dávila et al., J Endocrinol Invest 2004
(Osteoporosis) :
We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and
interleukin-1 stimulated interleukin (IL)-6,
transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Perrier d'Hauterive et al., Neuroimmunomodulation 2005
:
Contrastingly,
TGF-beta(1) ( from 10 ( -12 ) to 10 ( -8 ) M ), -beta ( 2 ), -beta ( 3 ) and activin A ( 10 ( -10 ) and 10 ( -8 ) M )
reduced IL-6 release by the same cells
François et al., Ann Rheum Dis 2006
(Disease Progression...) :
The immunohistological findings of a limited sample suggest a
role for BM in sacroiliitis, for TNFalpha and
IL6 in early, active lesions, and for
TGFbeta1 at the time of secondary cartilage and bone proliferation
Aoki et al., J Cell Biochem 2006
:
When anti-TGF-beta1 neutralizing antibody was added in the culture medium, IL-6 secretion from activated PSCs was inhibited, whereas exogenous
TGF-beta1 added in the culture medium
enhanced IL-6 expression and secretion by PSCs in a dose dependent manner ... We also demonstrated the reciprocal
effect of PSCs secreted
IL-6 on autocrine
TGF-beta1
Aoki et al., Am J Physiol Cell Physiol 2007
:
IL-6 as well as IL-1beta
enhanced TGF-beta1 secretion from PSCs
Shimizu et al., World J Gastroenterol 2006
(Bile Duct Neoplasms...) :
TGF-beta1 activates
IL-6 production, and the functional interaction between TGF-beta1 and IL-6 contributes to ICC cell growth by TGF-beta1
Matsuzaki et al., J Clin Endocrinol Metab 1992
:
To investigate the role of TGF beta 1 in placental hormonogenesis, we first studied the
effect of recombinant ( r )
TGF beta 1 on the production of
interleukin-6 (IL-6) and hCG by trophoblasts
Musso et al., J Immunol 1992
:
We have previously reported that
transforming growth factor-beta inhibits
IL-6 production in response to IL-1 beta
Hsiao et al., Cancer Immunol Immunother 2008
(Dog Diseases...) :
We previously reported that tumor infiltrating lymphocyte (TIL) derived
IL-6 inhibits
TGF-beta1 and restores natural killing ( NK ) activity
Turner et al., Eur J Immunol 1991
:
However,
TGF-beta 1 can
stimulate the production of
IL 6 and platelet derived growth factor, indicating that TGF-beta 1 initiates complex effects on the production of cytokines
Ichiyama et al., J Biol Chem 2008
:
However, in the
presence of
interleukin (IL)-6 ,
TGF-beta1 has also been found to promote differentiation into IL-17 producing helper T ( Th17 ) cells that are deeply involved in autoimmunity and inflammation
Lemaire et al., Mediators Inflamm 1996
:
In contrast,
TGF-beta(1) ( 0.5-50 ng/ml )
inhibited both LPS induced TNT and
IL-6 release by 50 % but had no effect on PGE ( 2 ) production by AM
Layh-Schmitt et al., Curr Opin Rheumatol 2008
(Spondylarthropathies) :
In mice,
transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages
promoting interleukin-17 production
Kitani et al., Mucosal Immunol 2008
:
It is now well established that although
transforming growth factor ( TGF ) -beta alone induces FoxP3 ( + ) regulatory T ( Treg ) cells, TGF-beta and
interleukin (IL)-6 , acting in concert,
induce differentiation of mouse naive T cells into Th17
Zhang et al., Nephrology (Carlton) 2009
:
Role of NAD ( P ) H oxidase in
transforming growth factor-beta1 induced monocyte chemoattractant protein-1 and
interleukin-6 expression in rat renal tubular epithelial cells ...
TGF-beta1 was also able to significantly
increase intracellular ROS ( P < 0.05 ), MCP-1 ( P < 0.01 ) and
IL-6 ( P < 0.05 ) expression in NRK-52E cells ... Further studies showed that generation of ROS and
upregulation of MCP-1 and
IL-6 by
TGF-beta1 were significantly blocked by addition of DPI or shRNA-p67phox ( P < 0.01 ), suggesting that these effects were NAD ( P ) H oxidase dependent ...
TGF-beta1 differentially regulates the expression of NAD ( P ) H oxidase subunits and
mediates MCP-1 and
IL-6 expression in rat renal tubular cells via the NAD ( P ) H oxidase/p67phox dependent mechanism
Morishima et al., Biochem Biophys Res Commun 2009
:
IL-6 augmented endogenous
TGF-beta1 mRNA expression, whereas the amount of TGF-beta produced was not enough to induce Th17 differentiation by IL-6 alone
Shen et al., Bioelectromagnetics 2010
(Osteoporosis) :
We, therefore, conclude that PEMF may affect bone remodeling process through promoting
TGF-beta1 secretion and
inhibiting IL-6 expression
Seong et al., Molecular vision 2009
:
In human Tenon 's fibroblasts,
TGF-beta1 stimulated the expression of alpha-SMA protein determined by western blot analysis and also
increased the mRNA levels of
IL-6 and IL-11 determined by multiplex RT-PCR
Nemunaitis et al., Eur J Haematol 1991
:
Neither interleukin-1 (IL-1)beta nor
IL-6 had an observable effect on
TGF beta 1 mRNA expression
Chen et al., J Pathol 2010
(Necrosis...) :
Using recombinant endoglin to inhibit the function of TGFbeta1 we have shown that the
TGFbeta1 does not directly
activate endothelial cells but rather it induces endothelial
IL-6 secretion ... Inhibiting either TGFbeta1 or IL-6 prevented endothelial cell activation in response to phagocytosing necrotic trophoblasts, but inhibiting
IL-6 did not
prevent secretion of
TGFbeta1 , confirming the order of signalling
Zenkel et al., Am J Pathol 2010
(Exfoliation Syndrome...) :
IL-6 and IL-8 were significantly up-regulated by ciliary epithelial cells in response to hypoxia or oxidative stress in vitro, whereas
IL-6 , but not IL-8,
induced the expression of
transforming growth factor-beta1 and elastic fiber proteins
Vyas et al., Ann Otol Rhinol Laryngol 2010
:
Inhibitory
effects of hepatocyte growth factor and
interleukin-6 on
transforming growth factor-beta1 mediated vocal fold fibroblast-myofibroblast differentiation ... Paradoxically,
IL-6 , which has been shown to play a profibrotic role in dermal studies, also
attenuated the
TGF-beta1 response
Turner et al., Cytokine 1990
:
In this study, we have examined the
effects of
TGF beta 1 on the production of
Interleukin 6 (IL 6) by human peripheral blood mononuclear cells ...
Induction of
IL 6 by
TGF beta 1 was specific, as other cytokines made by mononuclear cells ( TNF and IL 1 ) were not induced by TGF beta 1 ... Furthermore, when a panel of stimuli were compared for their ability to induce IL 1, TNF and
IL 6 in the
presence or absence of
TGF beta 1 , IL 6 levels were augmented in the presence of TGF beta 1, while the induction of IL 1 and TNF was inhibited significantly ... The ability of
TGF beta 1 to
induce IL 6 suggests that IL 6 may mediate some of the effects of TGF beta 1
Lotem et al., Blood 1990
(Leukemia, Myeloid) :
TGF-beta 1 suppressed the production of
IL-6 in normal bone marrow cells cultured with IL-1 alpha and the production of IL-6 and GM-CSF in leukemic cells cultured with IL-1 alpha or LPS
Musso et al., Blood 1990
:
We investigated the
effects of
transforming growth factor beta ( TGF beta ) on the induction by interleukin-1 beta (IL-1 beta) of
IL-6 in human monocytes
Espevik et al., Cell Immunol 1990
:
The
effect of recombinant ( r ) interleukin-1 beta ( rIL-1 beta ) and
transforming growth factor-beta ( TGF-beta ) on the production of interleukin-2 (IL-2) and
interleukin-6 (IL-6) from an antigen-specific ( LBRM-33-1A5 ) and an antigen-nonspecific ( EL-4-NOB-1 ) T-cell line was investigated
Lagneaux et al., Blood 1993
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Excessive production of
transforming growth factor-beta by bone marrow stromal cells in B-cell chronic lymphocytic leukemia
inhibits growth of hematopoietic precursors and
interleukin-6 production
Möller et al., Exp Dermatol 1994
(Carcinoma, Squamous Cell) :
Therefore, the
regulation of the production of the ubiquitous proinflammatory cytokine
interleukin 6 (IL-6) by
transforming growth factor beta ( TGF beta ) was investigated
Kuppner et al., Immunology 1995
:
We investigated the
effect of
transforming growth factor-beta ( TGF-beta ) on interleukin-1 beta (IL-1 beta) induction of
IL-6 and IL-8 mRNA levels and protein production by human RPE cells
Gibellini et al., Br J Haematol 1994
:
Moreover,
IL-6 appeared
involved in the up-regulation of
TGF-beta 1 , because the addition of a neutralizing anti-IL-6 antibody to Tat treated PB monocyte cultures significantly reduced the amounts of TGF-beta 1 recovered in the culture supernatants after 96 h
Matthes et al., Eur J Immunol 1995
:
On the other hand, and in contrast to the suppression of B cell proliferation and Ig secretion, the basal or the
IL-6/IL-10 stimulated Ig secretion of nonproliferating cells was not
inhibited by recombinant
TGF-beta 1
Reinhold et al., Cytokine 1994
:
In this study we have analysed in parallel the
effects of
TGF-beta 1 on both DNA synthesis and production of the cytokines IL-1, IL-2,
IL-6 , and TNF-alpha by pokeweed mitogen stimulated peripheral blood mononuclear cells ... With this stimulation system we show that
TGF-beta 1 at a concentration of 15 ng/ml significantly
suppresses IL-2 and
IL-6 production
Gautam et al., Oncol Res 1993
(Astrocytoma) :
Interferon gamma (IFN gamma),
transforming growth factor beta 1 ( TGF-beta 1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ) and granulocyte-colony stimulating factor ( G-CSF ) did not
induce IL6 mRNA production ; however, IL6 mRNA expression and protein production was strongly induced by IL1 alpha and to a lesser extent by IFN alpha ... The
IL6 mRNA expression induced by IL1 alpha was
potentiated by
TGF-beta 1 and IFN alpha and slightly decreased by IFN gamma
Matsuzaki et al., Nihon Sanka Fujinka Gakkai Zasshi 1994
(Chorioamnionitis) :
However,
transforming growth factor-beta ( TGF-beta )
suppressed these cytokine mediated hCG production as well as
IL-6 production
McGee et al., J Immunol 1993
:
In a previous study,
transforming growth factor-beta ( TGF-beta 1 ) was also found to
enhance IL-6 secretion by the IEC-6 cells and because both IL-1 beta and TGF-beta may be present in inflamed mucosal tissue, the effect of adding both cytokines together was next investigated
Villiger et al., J Immunol 1993
:
Analysis by Northern blotting showed that
IL-6 induced
TGF-beta 1 gene expression but had no detectable effect on TGF-beta 2 mRNA levels and marginally increased TGF-beta 3 mRNA ... Consistent with the effects on TGF-beta 1 mRNA,
IL-6 increased the synthesis of
TGF-beta 1
Danforth et al., Cancer Res 1993
(Breast Neoplasms) :
IL-1, but not
IL-6 ,
increased secretion of
transforming growth factor-beta ( TGF-beta ) by 2.45-fold over 72 h ( P < 0.01 )
Osawa et al., Nephrol Dial Transplant 1995
:
Secretion of
IL-6 by GECs was
increased by
transforming growth factor beta but not by IL-1 beta
Bodine et al., J Bone Miner Res 1996
:
This cell line secretes
TGF-beta 1 and interleukin-6 (IL-6) at 34 degrees C, but only the basal secretion of
IL-6 increases 70 % at 40 degrees C
Kumar et al., J Cell Physiol 1996
:
Induction of
interleukin-1 and interleukin-8 mRNAs and proteins by
TGF beta 1 in rat lung alveolar epithelial cells
Hedges et al., Cytokine 1996
:
IL-4, IL-13, IFN-gamma, and
TGF-beta 1 , but not IL-2, IL-5, IL-10 or IL-12,
stimulated IL-6 secretion ... IL-5, IL-12, IL-13 and
TGF-beta 1 additively
enhanced the bacterially induced
IL-6 secretion, but they did not affect IL-8 secretion
Karres et al., Arch Surg 1996
:
Moreover,
TGF-beta 1 inhibited mRNA expression of tumor necrosis factor alpha and
IL-6 in a dose dependent manner
Spittler et al., Immunology 1997
:
Both constitutive and interferon-gamma (IFN-gamma), interleukin-4 (IL-4),
IL-6 and tumour necrosis factor-alpha (TNF-alpha) induced human leucocyte antigen ( HLA ) -DR, HLA-DP and HLA-DQ Ag expression on monocytes was significantly
down-regulated by calcitriol, IL-10 and
transforming growth factor-beta ( TGF-beta )
Marth et al., Eur J Immunol 1997
:
Regulation of
transforming growth factor-beta production by
interleukin-12
Fischer et al., Eur J Immunol 1997
(Toxoplasmosis, Animal) :
The
IL-6 response of parasitized astroglia was
up-regulated by external tumor necrosis factor (TNF)-alpha and
transforming growth factor (TGF)-beta 1 , with only TNF-alpha enhancing simultaneous release of IL-1
Mazzarelli et al., J Neuroimmunol 1998
:
Effect of
transforming growth factor-beta1 on
interleukin-6 secretion in human myoblasts ... In the present report, we show that
TGF-beta1 can
induce IL-6 production ; moreover, costimulation or short term pre-incubation with TGF-beta1 increases IL-1beta effect, while a longer incubation inhibits its action
Brady et al., J Dent Res 1998
:
Our results further show that, within 4 hrs, exogenously applied
TGF-beta1 down-regulated
IL-6 expression in a dose dependent manner, and this inhibition was sustained over a six-day period
Fulton et al., J Infect Dis 1998
:
Regulation of
interleukin-12 by interleukin-10,
transforming growth factor-beta , tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Spyridonidis et al., Blood 1999
(Ascites...) :
Expansion of clonogenic tumor cells was seen in the
presence of SCF + IL-1beta + IL-3 +
IL-6 + EPO, but was suppressed by
TGF-beta1