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BCL3 — IL6
Text-mined interactions from Literome
Puthier et al., Br J Haematol 1999
(Multiple Myeloma) :
In a system of apoptosis by growth factor deprivation on myeloma cells, we showed that the effect of Bcl-2 seemed minimal whereas Mcl-1 and
Bcl-xL were tightly
regulated by
interleukin (IL)-6
Kuwata et al., Blood 2003
:
Lentiviral vector mediated expression of
Bcl-3 inhibited lipopolysaccharide (LPS) induced production of tumor necrosis factor alpha (TNF-alpha), but not
IL-6 , in macrophages ... Overexpression of
Bcl-3 suppressed activation of the TNF-alpha promoter, but not the
IL-6 promoter
Pu et al., Prostate 2004
(Prostatic Neoplasms) :
Among Bcl-2 family proteins, only
Bcl-xL was evidently
increased by
IL-6 stimulation
Brocke-Heidrich et al., Oncogene 2006
(Multiple Myeloma) :
BCL3 is
induced by
IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription ... In this study,
interleukin (IL)-6 induced
BCL3 expression and its effect on survival of multiple myeloma ( MM ) cells were examined ... We demonstrate the
upregulation of
BCL3 by
IL-6 in INA-6 and other MM cell lines ... Mutation of the Stat motifs within HS4 abolished
IL-6 dependent
BCL3 induction
Brenne et al., Eur J Haematol 2009
(Multiple Myeloma) :
Bcl-3 was
induced in myeloma cell lines by
interleukin (IL)-6 , IL-21, IL-15, tumor necrosis factor-alpha and IGF-1, and its upregulation was associated with increased proliferation of the cells
Dagvadorj et al., Innate Immun 2009
:
In the presence of
Bcl-3 , siRNA IL-10 failed to
inhibit LPS induced
IL-6 production
Ahlqvist et al., Oncogene 2013
(Prostatic Neoplasms) :
Elevated
Bcl-3 expression in PCa was
dependent on the proinflammatory cytokine
interleukin-6 mediated STAT3 activation
Kathiria et al., Cancer Res 2012
(Colitis...) :
In wild-type p53 cells, PHB overexpression decreased basal and
interleukin-6 induced STAT3 activation and expression of the STAT3 responsive genes
Bcl-xL and Bcl-2
Oritani et al., Blood 1999
:
During this process,
IL-6 downregulated expression of BCL2 in 1A9-M cells and
stimulated BCL-XL expression, but had no effect on p53, Bax, or Bak gene expression