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CEBPA — IL6
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chen et al., FEBS Lett 1999
:
Treatment of freshly isolated adult rat hepatocytes with 10-100 mM ethanol rapidly ( < 3 min ) inhibits
interleukin-6 (IL-6) induced STAT3 activation, tyrosine and serine phosphorylation and IL-6 induced CCAAT enhancer binding protein
(C/EBP) alpha and beta mRNA expression
Hungness et al., J Cell Physiol 2002
:
This effect of IL-1beta was reduced by approximately 30 % when the C/EBP binding site in the IL-6 promoter was mutated, supporting a
role of
C/EBP in the regulation of
IL-6 production
Vales et al., J Biol Chem 2002
:
Binding of
C/EBP and RBP ( CBF1 ) to overlapping sites
regulates interleukin-6 gene expression
Foka et al., Nucleic Acids Res 2003
(Carcinoma, Hepatocellular) :
Interleukin-6 represses the transcription of the
CCAAT/enhancer binding protein-alpha gene in hepatoma cells by inhibiting its ability to autoactivate the proximal promoter region
Liao et al., J Biol Chem 2004
:
Although activation of
interleukin-6-STAT3 signaling,
regulation of expression of hepatic
C/ebpalpha , C/ebpbeta, cyclin D, and cyclin E and progression through the first wave of hepatocellular DNA synthesis occurred appropriately following partial hepatectomy in Egr-1 null mice, subsequent signaling events and cell cycle progression after the first round of DNA synthesis were deranged
Shamsasenjan et al., Int J Hematol 2009
(Multiple Myeloma) :
It was confirmed that introduction of shRNA for MYC into a CD33 ( + ) myeloma cell line blocked the
IL-6 induced down-regulation of CD33 and
CEBPA expression
Allen et al., Am J Physiol Regul Integr Comp Physiol 2010
(Calcium Signaling) :
Finally, CREB and
C/EBP were necessary for basal IL-6 promoter activity and
sufficient to increase
IL-6 promoter activity but had minimal roles in calcineurin activated IL-6 promoter activity
Chen et al., J Urol 2013
(Carcinoma, Transitional Cell...) :
RGD-MAP8 was used to determine its effect on signaling pathway
activation ( nuclear factor-?B, NRF2 and
CEBP ), gene expression ( p21,
interleukin-6 and 8, CXCL1, CXCL2 and CCL20 ) and cytotoxicity ( trypan blue exclusion and HMGB1 release ) in human urothelial carcinoma cells
Kordula et al., Biochem J 1996
:
The
role of Stat and
C/EBP transcription factors in the synergistic activation of rat serine protease inhibitor-3 gene by
interleukin-6 and dexamethasone
Xia et al., Int J Biochem Cell Biol 1997
(Acute-Phase Reaction) :
In addition,
C/EBP beta and C/EBP delta, but not C/EBP alpha, bind specifically to the C/EBP site of SAA2 in
response to
IL-6 stimulation
Zhang et al., J Exp Med 1998
:
Upregulation of
interleukin 6 and granulocyte colony stimulating factor receptors by transcription factor
CCAAT enhancer binding protein alpha ( C/EBP alpha ) is critical for granulopoiesis