Gene interactions and pathways from curated databases and text-mining

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ERBB3 — IL6

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: ERBB3 → IL6 (increases) Qiu et al., Nature 1998*
    Evidence: When LNCaP cells were treated with IL6 Erbb3 and Erbb2 proteins were tyrosine phosphorylated. With them all the three isoforms of Shc proteins were also phosphorylated.
  • OpenBEL Selventa BEL large corpus: ERBB3 → IL6 (increases) Qiu et al., Nature 1998*
    Evidence: When LNCaP cells were treated with IL6 Erbb3 proteins were tyrosine phosphorylated.
  • OpenBEL Selventa BEL large corpus: ERBB3 → IL6 (increases) Qiu et al., Nature 1998*
    Evidence: treatment of the prostate cancer cell line LNCaP with IL-6 induces tyrosine phosphorylation of ErbB2 and ErbB3, but not ErbB1/EGFR. We also show that ErbB2 forms a complex with the gp130 subunit of the IL-6 receptor