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CREB3 — EGFR
Text-mined interactions from Literome
Tokunou et al., Arterioscler Thromb Vasc Biol 2001
:
Inhibition of the
epidermal growth factor receptor by AG1478 also
inhibited the thrombin induced
CREB phosphorylation
Funakoshi et al., J Biol Chem 2002
:
Inhibition of
epidermal growth factor-receptor by AG1478
suppressed the AngII induced
CREB phosphorylation as well as activation of ERK and p38MAPK
Fukuyama et al., Biochem Biophys Res Commun 2005
(Hypertrophy) :
Inhibition of
epidermal growth factor receptor (EGFR) and mitogen- and stress activated protein kinase-1 also
suppressed PGF ( 2alpha ) -induced
CREB phosphorylation
Pham et al., J Cell Physiol 2008
:
The p38 ( MAPK ) selective inhibitor, SB202190, but not the MEK selective inhibitor, PD98059, or the
EGFR kinase inhibitor, AG1478,
inhibited Ang II-dependent COX-2 expression and
CREB phosphorylation
Yeh et al., Differentiation 2012
:
Together, these results demonstrate that ß-adrenergic stimulation activates diverse cell survival and progrowth signaling pathways, including cAMP and
EGFR linked activation of ERK1/2, p38MAPK, and p70S6K, and also induction of ß2-ARs, possibly
mediated by
CREB and NF-?B, resulting in salivary gland enlargement