Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
MYC
→
Complex of CUL1-RBX1-SKP1-SKP2
(increases, CUL1/RBX1/SKP1/SKP2 Activity)
Evidence: It has been reported that during the G1 to S transition of the cell cycle, Skp2 regulates the ubiquitinylation and stability of the transcription factor c-Myc, an oncoprotein that plays a major role in oncogenesis Skp2 enhances c-Myc-induced S phase transition and activates c-Myc transcriptional activity.