◀ Back to MYC
MYC — YY1
Pathways - manually collected, often from reviews:
-
FastForward regulation:
YY1, NOTCH1
→
MYC
(transcriptional regulation, increase)
Hsu et al., Mol Cell Biol 2008
Evidence: PROMACTIVITY, DNABINDING
-
NCI Pathway Database Notch signaling pathway:
NICD/YY1 complex (YY1-NOTCH1)
→
MYC (MYC)
(transcription, activates)
Satoh et al., J Biol Chem 2004*, Weng et al., Genes Dev 2006*, Palomero et al., Proc Natl Acad Sci U S A 2006*, Liao et al., Carcinogenesis 2007*, Hsu et al., Mol Cell Biol 2008
Evidence: mutant phenotype, reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
YY1
—
MYC
(direct interaction, two hybrid)
Shrivastava et al., Science 1993*
-
IRef Biogrid Interaction:
YY1
—
MYC
(direct interaction, pull down)
Shrivastava et al., Science 1993*
-
IRef Dip Interaction:
MYC
—
YY1
(physical association, two hybrid)
Shrivastava et al., Science 1993*
-
IRef Dip Interaction:
MYC
—
YY1
(physical association, affinity chromatography technology)
Shrivastava et al., Science 1993*
-
IRef Hprd Interaction:
YY1
—
MYC
(in vitro)
Shrivastava et al., Science 1993*
-
IRef Hprd Interaction:
YY1
—
MYC
(two hybrid)
Shrivastava et al., Science 1993*
-
IRef Ophid Interaction:
MYC
—
YY1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Hasegawa et al., J Immunol 2001
:
These data indicate that the decreased association of YY1 with
c-Myc that is caused by impaired interaction in the c-Myc/Max/Mad network
results in increased binding activity of
YY1 to the CXCR4 promoter, mediating down-regulation of CXCR4 production in HHV-6 infected cells
de Nigris et al., Oncogene 2007
(Bone Neoplasms...) :
YY1 regulated negatively the
Myc activity through a direct interaction with the Myc/Max and deacetylase complexes
Neri et al., Mol Cell Biol 2012
:
Myc regulates the transcription of the
PRC2 gene to control the expression of developmental genes in embryonic stem cells