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CNTF — PRKAG2
Text-mined interactions from Literome
Steinberg et al., Endocrinology 2006
(Obesity) :
Intracerebroventricular
CNTF ( Ax15 ) reduced food intake, increased arcuate nucleus (ARC) signal transducer and activator of transcription 3 phosphorylation, and
reduced AMPK signaling but not in the paraventricular nucleus ( PVN ), posterior hypothalamus, or cortex ... Both leptin and
CNTF reduced
AMPK activity and acetyl-coenzyme A carboxylase phosphorylation in the ARC and PVN of control fed mice ... A HFD blunted leptin but not
CNTF effects on
AMPK signaling in the ARC and PVN
Escartin et al., J Neurosci 2007
:
CNTF significantly
increased the phosphorylation level of the intracellular energy sensor
AMP activated protein kinase (AMPK) , supporting a specific reorganization of brain energy pathways
Hu et al., Hepatology 2008
(Carcinoma, Hepatocellular...) :
Furthermore,
CNTF induced mitogen activated protein kinase ( MAPK ) activation
suppresses AMPK activity in the early phase of CNTF stimulation
Steinberg et al., Diabetes 2009
(Obesity) :
The
effects of
CNTF on skeletal muscle glucose uptake and
AMPK/Akt signaling were investigated in incubated soleus and extensor digitorum longus (EDL) muscles from muscle-specific AMPKalpha2 kinase-dead, gp130 ( DeltaSTAT ), and lean and obese ob/ob and high-fat fed mice