Gene interactions and pathways from curated databases and text-mining

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PRKCA — RELA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Yang et al., J Immunol 2001 : The involvement of a conventional PKC isoform was confirmed by the finding that expression of PKCalpha enhanced the effect of Galpha(16), and a dominant negative PKCalpha partially blocked Galpha(16) mediated NF-kappaB activation
Lee et al., Cancer Chemother Pharmacol 2004 : For experimentally induced tumor promotion, we investigated whether the SNL glycoprotein was able to regulate the activity of protein kinase C alpha (PKCalpha) , the DNA binding activation of nuclear factor-kappa B (NF-kappaB) , the activity of NF-kappaB protein, and the production of nitric oxide ( NO ) in HCT-116 cells stimulated with 12-O-tetradecanoylphorbol 13-acetate ( TPA ) using electrophoretic mobility shift assays ( EMSA ), Western blot analysis, and NO assays
Gopee et al., Cell Biol Toxicol 2004 : The aim of current study was to investigate the effect of PKCalpha activation by FB1 on NF-kappaB activation and subsequently on TNFalpha gene expression and caspase 3 induction in LLC-PK1 cells ... In summary, we hereby demonstrate that the FB1 activation of NF-kappaB and sequential induction of TNFalpha expression resulting in the subsequent increase in caspase 3 activity are all dependent on PKCalpha stimulation in LLC-PK1 cells
Asehnoune et al., Cell Signal 2005 : PKCalpha/beta can regulate NF-kappaB dependent transcription in neutrophils both by enhancing nuclear translocation of NF-kappaB and also by stimulating phosphorylation of the p65 subunit
Zhu et al., J Steroid Biochem Mol Biol 2004 (MAP Kinase Signaling System) : This effect may be associated with the decreased expression of p27, the increased expression of PKC-alpha , and the activation of NF-kappaB
Rouquette-Jazdanian et al., J Immunol 2005 : Combined all together : raft modification in terms of lipids, ceramide production, protein kinase Calpha inhibition , and NF-kappaB activation lead to CD4+ T cell inhibition
Bolick et al., Arterioscler Thromb Vasc Biol 2006 : Inhibition of rhoA and PKCalpha significantly reduced NF-kappaB activation, ICAM-1 induction, and monocyte adhesion to aorta
Paria et al., J Biol Chem 2006 : Inhibition of store Ca ( 2+ ) depletion, buffering of intracellular Ca ( 2+ ), or down-regulation of protein kinase Calpha downstream of Ca ( 2+ ) influx all blocked thrombin induced NF-kappaB activation and the resultant TRPC1 expression in endothelial cells
Banzi et al., Biochem Biophys Res Commun 2006 : Polycystin-1 promotes PKCalpha mediated NF-kappaB activation in kidney cells ... CTT dependent NF-kappaB promoter activation was mediated by PKCalpha because it was blocked by its specific inhibitor Ro-320432 ... These data reveal, therefore, a novel pathway by which polycystin-1 activates a PKCalpha mediated NF-kappaB signalling and cell survival
Liao et al., Neurochem Int 2007 : The inductive action of manganese was accompanied by generation of oxidative stress, activation of mitogen activated protein kinases ( MAPKs ), AKT, and protein kinase C-alpha (PKC-alpha) , and increased NF-kappaB and AP-1 DNA binding activities
Horovitz-Fried et al., Biochem Biophys Res Commun 2007 : Thus, PKCalpha regulates insulin induced PKCdelta expression levels and this regulation involves activation of SP-1 and NFkappaB
Chun et al., J Pharm Pharmacol 2007 : Furthermore, ergolide mediated protein kinase Calpha (PKCalpha) inhibition is involved in reduction of NF-kappaB inhibition, as demonstrated by the observation that dominant negative PKCalpha, but not p44/42 MAPK and p38 MAPK, inhibits TPA stimulated reporter gene expression
Mahanivong et al., Oncogene 2008 (Neoplasm Invasiveness...) : Although constitutively active mutants of PKCalpha ( a cPKC ), PKCtheta ( a novel PKC ( nPKC ) ) and PKCzeta ( an atypical PKC ( aPKC ) ) were all able to activate NF-kappaB and upregulate uPA expression, only dominant negative PKCalpha mutant attenuated LPA induced NF-kappaB activation and uPA upregulation
Kanetaka et al., Exp Cell Res 2008 : Together, these results demonstrate that IFN-alpha causes a transient upregulation of c-FLIP expression, at least through PKCalpha mediated activation of NF-kappaB
Langlet et al., Eur J Immunol 2010 : Dominant negative PKC-alpha inhibited NF-kappaB reporter activity mediated by overexpression of MyD88 but not TRIF
Chao et al., J Agric Food Chem 2010 : By means of confocal microscope analysis we demonstrated that phosphorylation and membrane translocation of protein kinase C-alpha , as well as NF-kappaB activation , were inhibited by honokiol in LPS stimulated macrophages
Mut et al., Turk Neurosurg 2010 (Glioblastoma) : The activation of NF-kappaB by PKC alpha and PKC delta was assessed by Western blotting after the stimulation with Phorbol 12- Myristate 13-Acetate ( PMA )