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EGF — MAP2K2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAP2K2 → EGF (increases) Olsen et al., Cell 2006*
  Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database

Text-mined interactions from Literome

Kato-Stankiewicz et al., Proc Natl Acad Sci U S A 2002 (MAP Kinase Signaling System) : They also inhibited Ras induced Raf-1 activation in human embryonic kidney 293 cells, Raf-1 and mitogen activated protein kinase kinase 1 activities in HT1080 fibrosarcoma cells, and epidermal growth factor induced Raf-1 activation in A549 lung carcinoma cells
Yamasaki et al., Oncogene 2003 (Cell Transformation, Neoplastic) : EGF dependent activation of c-Raf and Mek1/2 , which function upstream of ERKs, was perturbed in Gab1-/- cells
Hyder et al., Cell communication and signaling : CCS 2012 : Phosphoimmunoblotting of PCMOs indicated that both EGF and HB-EGF activated MEK-1/2 and ERK1/2 in a concentration dependent fashion with the effect of EGF being more prominent
Gilmartin et al., J Cell Biol 1984 : Neither cyclic GMP, Ca++, hydrocortisone, nor epidermal growth factor had any effect on the phosphorylation of MEK-1 or MEK-2
Moriguchi et al., Eur J Biochem 1995 : Activation of two isoforms of mitogen activated protein kinase kinase in response to epidermal growth factor and nerve growth factor ... In rat fibroblastic 3Y1 cells, epidermal growth factor (EGF) treatment induced activation of both MAPKK1 and MAPKK2 ... In PC12 cells, both MAPKK1 and MAPKK2 were activated in response to nerve growth factor (NGF) as well as EGF , and the time courses of activation and deactivation of both isoforms were indistinguishable from each other in the NGF stimulated cells and also in the EGF stimulated cells ... Furthermore, localization of both MAPKK1 and MAPKK2 in the cytoplasm was unchanged in response to EGF and NGF
Silvy et al., Endocrinology 1998 : Whereas no significant effect of 10 ( -12 ) M EGF could be detected, 10 ( -9 ) M EGF was shown to activate MEK1 and, to a lesser extent, MEK2
Kitano et al., Am J Physiol 1998 : PD-098059, a specific inhibitor of MEK, inhibited EGF stimulated MEK1 and MEK2 activities in hepatocytes from 6- and 24-mo-old rats