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RAC2 — RHOA

Pathways - manually collected, often from reviews:

• KEGG Regulation of actin cytoskeleton: RHOA → RAC1/RAC2/RAC3 (protein-protein, inhibition)
• Reactome Reaction: RAC2 → RHOA (reaction) Hirotani et al., Biochem Biophys Res Commun 2002, Oinuma et al., J Biol Chem 2003, Swiercz et al., J Cell Biol 2004
• WikiPathways Regulation of Actin Cytoskeleton: RHOA → RAC1/RAC3/RAC2 (inhibition)

Text-mined interactions from Literome

Pertz et al., Nature 2006 : Current models postulate that Rac promotes membrane protrusion at the leading edge and that RhoA regulates contractility in the cell body
Matthews et al., Development 2008 : In addition, we show that RhoA inhibits Rac in NC cells
Wu et al., Nature 2009 : Rac was shown to inhibit RhoA in mouse embryonic fibroblasts, with inhibition modulated at protrusions and ruffles
Alcaide et al., Am J Physiol Cell Physiol 2012 : Interestingly, overexpression of either p120-4A or p120-1A dramatically blocked TEM, and overexpression of p120-1A in HUVEC did not affect RhoA basal activity or activation of RhoA and Rac induced by thrombin or ICAM-1 crosslinking
Sells et al., Curr Biol 1997 : In mammalian cells, Cdc42 regulates the formation of filopodia, whereas Rac regulates lamellipodia formation and membrane ruffling, and RhoA regulates the formation of stress fibers