◀ Back to TNF

AHSA1 — TNF

Text-mined interactions from Literome

Ajizian et al., J Infect Dis 1999 : Whether p38 and extracellular signal regulated kinase ( ERK ) mitogen activated protein kinase cascades are required for inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in RAW 264.7 murine macrophages exposed to lipopolysaccharide (LPS) plus recombinant interferon-gamma ( rIFN-gamma ) was investigated
Takehana et al., Biochem Biophys Res Commun 1999 : Furthermore, LL-Z-1640-2 inhibited anisomycin induced but not TNF induced JNK/p38 activation, indicating that the inhibition mechanism is signal-specific
Kraatz et al., J Surg Res 1999 : Macrophage TNF secretion in endotoxin tolerance : role of SAPK, p38 , and MAPK
Matsumoto et al., FEBS Lett 2000 : In RAW264 cells which differentiate into osteoclast-like multinucleated cells by TNF treatment alone, activation of p38 mitogen activated protein ( MAP ) kinase induced by murine TNF was comparable to and independent of the receptor activator of necrosis factor-kappaB ligand
Bowie et al., J Immunol 2000 : Inhibition of TNF-driven IKK activation was mediated by p38 mitogen activated protein kinase, because treatment of cells with vitamin C led to a rapid and sustained activation of p38, and the specific p38 inhibitor SB203580 reversed the inhibitory effect of vitamin C on IKK activity, I-kappaBalpha phosphorylation, and NF-kappaB activation
Chae et al., Bone 2001 (MAP Kinase Signaling System) : In this study, TNF-alpha stimulated NF-kappaB binding affinity as well as p38 MAP kinase activation, leading to the release of IL-6
Hashimoto et al., Clin Exp Allergy 2001 : The results showed that : NAC attenuated TNFalpha induced p38 MAP kinase activation and RANTES production ; SB 203580 as the specific inhibitor of p38 MAP kinase activity attenuated TNF-alpha induced RANTES production ; BSO facilitated TNF-alpha induced p38 MAP kinase activation and RANTES production ; SB 203580 attenuated BSO mediated facilitation of TNF-alpha induced RANTES production ; and the intracellular GSH increased in NAC treated cells, whereas the intracellular GSH was reduced in BSO treated cells
Robinson et al., Cell Signal 2001 : In cells expressing either wild-type ( WT ) or catalytically inactive ( CI ) -MKP-2, there was no significant differences in TNFalpha stimulated JNK or p38 MAP kinase activity, however hydrogen peroxide ( H2O2 ) -stimulated JNK activity was substantially reduced in WT-MKP-2 expressing clones and enhanced in cells expressing CI-MKP-2
Ballard-Croft et al., Am J Physiol Heart Circ Physiol 2001 (Burns) : SB203580 inhibited p38 MAPK activity, reduced myocyte secretion of TNF-alpha , and prevented burn mediated cardiac deficits
Yan et al., Cancer Res 2001 (MAP Kinase Signaling System) : However, TNF activation of p38 or stress activated protein kinase/c-Jun NH ( 2 ) -terminal kinase is not inhibited by disruption of KSR signaling
Webb et al., J Dent Res 2002 (Osteosarcoma) : In conclusion, although p38 MAPK activation by TNF-alpha stimulates IL-6 secretion by MG-63 cells, it has opposing effects on c/EBPbeta and NFkappaB activity
Monier et al., J Infect Dis 2002 : The role of p38- and extracellular signal regulated kinase ( ERK ) mitogen activated protein ( MAP ) kinase pathways in the up-regulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) production in macrophages stimulated with Streptococcus pneumoniae was examined
Mancuso et al., J Immunol 2002 : Selective inhibitors of ERK 1/2 ( PD98059 or U0126 ), p38 ( SB203580 ), or NF-kappa B ( caffeic acid phenetyl ester ( CAPE ) ) could all significantly reduce TNF-alpha production, although none of the inhibitors used alone was able to completely prevent TNF-alpha release
Guo et al., J Biol Chem 2003 (Inflammation) : Here we show unequivocally that the production of interleukin (IL)-1beta, IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha) requires p38 MAPK activity by demonstrating that the inhibitory effects of SB 203580 were reversed by expression of an SB 203580-resistant form of p38alpha ( SBR-p38alpha ) that fails to bind to SB 203580
Clermont et al., Cell Signal 2003 : These results indicate that TNF activates NF-kappaB, which does not drive any anti-apoptotic response, and p38 , which plays an anti-apoptotic function probably through HSP27 phosphorylation
Klein et al., Cardiovasc Toxicol 2002 : This study was undertaken to examine the relationship between TNF induced cardiomyocyte apoptosis and activation of p38 mitogen activated protein kinase ( MAPK ) through oxidative stress
Gee et al., J Biol Chem 2003 : Subsequently, TNF-alpha mediated p38 MAPK activation induced sialidase activity and CD44-HA binding
Tanno et al., J Mol Cell Cardiol 2003 (MAP Kinase Signaling System...) : These findings suggest that the pre-ischemic activation of p38-MAPK by TNF does not contribute to cardioprotection afforded by this agent
Alcaide et al., Eur J Immunol 2004 (Chagas Disease) : In contrast, AgC10 did not affect p38 activation induced by TNF
Grethe et al., Exp Cell Res 2004 : Taken together, our results suggest that TNF induced p38 MAPK mediated phosphorylation of Bcl-x ( L ) in endothelial cells leads to degradation of Bcl-x ( L ) in proteasomes and subsequent induction of apoptosis
Farivar et al., J Heart Lung Transplant 2004 (Bronchiolitis Obliterans...) : p38 regulates the expression of the cytokines tumor necrosis ( TNF)-alpha and interleukin (IL)-1beta, 2 mediators involved in the development of OB in a tracheal transplant model
Chen et al., J Leukoc Biol 2004 (Endotoxemia) : Pharmacological suppression of p38 or ERK1/2 MAPK with specific inhibitors ( SB203580, SB202190, U0126, or PD98059 ) significantly attenuated LPS induced TNF production but failed to inhibit LPS induced HMGB1 release
Kim et al., Int Immunopharmacol 2004 : PA and TNF-alpha increased the phosphorylation of extracellular signal regulated kinase ( ERK ) -1/2, p38-kinase , and c-Jun N-terminal kinase (JNK) by Western blotting
Aleshin et al., Eur J Cardiothorac Surg 2004 (Myocardial Reperfusion Injury) : FR167653 administered before ischemia and during reperfusion significantly reduced ischemia activated myocardial TNFalpha mRNA expression ( 190+/-97 vs. 4805+/-3017, P=0.024 ) as well as TNFalpha production ( 0 vs. 9.6+/-2.5 ng/ml, P < 0.05 ) and also inhibited p38 MAPK activation
Zhu et al., J Biol Chem 2005 (Inflammation) : Furthermore, p38 is critical for the production of IL-6 and IL-12 but is only marginally required for the production of TNF-alpha and nitric oxide
Yamawaki et al., J Clin Invest 2005 (Inflammation) : In cultured ECs, reduction of TXNIP expression by small interfering RNA increased TRX binding to ASK1 and inhibited TNF activation of JNK/p38 and VCAM1 expression
Ramesh et al., American journal of physiology. Renal physiology 2005 (Kidney Diseases) : p38 MAPK activation leads to increased production of TNF-alpha in ischemic injury and in macrophages ... Inhibition of p38 MAPK activation led to inhibition of TNF-alpha production
Wang et al., J Biol Chem 2005 : In stimulated cells, DHP-2 at 200 nM or MLK7 small interfering RNA completely blocked anisomycin and UV induced but had no effect on interleukin-1beta or tumor necrosis factor-alpha induced p38 and JNK activation
Samuel et al., Pancreatology 2005 (Acute Disease...) : We hypothesize that bile-pancreatic juice exclusion activates p38 ( MAPK ) and induces TNF-alpha production in ligation induced acute pancreatitis
Maung et al., J Leukoc Biol 2005 (Burns) : Using the specific p38 inhibitor ( SB203580 ), we confirmed that the increase in tumor necrosis factor alpha production by LPS stimulated burn macrophages requires p38 activation
Görtz et al., Arthritis Res Ther 2005 (Arthritis...) : These data indicate that TNF preferentially activates p38MAPKalpha and ERK in synovial membrane exposed to TNF
Dodeller et al., Eur J Immunol 2005 : In contrast, inhibition of p38 activity did not affect expression of the Th1 cytokines IFN-gamma and TNF induced by TCR-stimulation, but decreased IL-12 mediated IFN-gamma expression
Beers et al., Biochemistry 2006 : These results suggest that TNF alpha suppresses apoAI promoter activity through both the MEK/ERK and JNK pathways but is not mediated by either p38 MAP kinase activity or NF-kappaB activation
Ahn et al., J Biol Chem 2006 : Further, the deletion of NQO1 abolished TNF induced c-Jun N-terminal kinase, Akt, p38 , and p44/p42 mitogen activated protein kinase activation
Thirunavukkarasu et al., Hepatology 2006 (Disease Models, Animal...) : Inhibition of p38 and NF-kappaB activation by SB203580 and pyrrolidine dithiocarbamate, respectively, blocked endotoxin induced H ( 2 ) O ( 2 ), NO, TNF-alpha , and IL-6 synthesis
Bellahcene et al., J Am Coll Cardiol 2006 : Under conditions of constant coronary flow, the p38-MAPK activation and contractile depression induced by TNFalpha , though attenuated, remained sensitive to the absence of MKK3 or the presence of SB203580
Ulanova et al., Biochem Biophys Res Commun 2006 : Inhibition of Syk down-regulated TNF induced p38 and p44/42 MAPK phosphorylation and nuclear translocation of p65 NF-kappaB
Uchide et al., Intervirology 2007 : We investigated the involvement of p38 mitogen activated protein ( MAP ) kinase in tumor necrosis factor (TNF)-alpha gene expression, apoptosis induction and virus replication in cultured human fetal membrane chorion cells infected with influenza virus
Kunisch et al., Ann Rheum Dis 2007 (Arthritis, Rheumatoid...) : In RA- and OA-SFB, TNFalpha induced phosphorylation of p38 , ERK or JNK was exclusively mediated by TNF-R1
Prickett et al., Mol Cell Biol 2007 : Overexpression of alpha-4 suppressed p38 MAPK activation in response to tumor necrosis factor alpha (TNF-alpha)
Tesz et al., J Biol Chem 2007 (Inflammation...) : TNFR1, but not TNFR2, also mediates a potent effect of TNFalpha on the phosphorylation of JNK1/2 and p38 stress activated protein kinase and their downstream transcription factor substrates c-Jun and activating transcription factor 2 (ATF2)
Deleault et al., Mol Immunol 2008 (MAP Kinase Signaling System) : To further characterize the control of TTP function, we examined the combinatorial effect of p38 , ERK and JNK activation on TNF-alpha post-transcriptional expression and TTP function
Ahn et al., Cancer Res 2007 (Skin Neoplasms) : Deletion of NQO2 also abolished TNF induced c-Jun NH2-terminal kinase, Akt, p38 , and p44/p42 mitogen activated protein kinase activation
Yin et al., Inflammation 2008 (Disease Models, Animal...) : The purpose of this study was to test our hypothesis that p38 mitogen activated protein kinase ( p38 MAPK ) inhibitor SB203580 may favorably affect tumor necrosis factor alpha (TNFalpha) secretion and left ventricular ( LV ) remodeling after myocardial ischemia ( MI )
Miyazawa et al., J Toxicol Sci 2008 (MAP Kinase Signaling System) : Inhibition of p38 MAPK activation selectively blocked DNCB induced TNF-alpha release, but not NiSO ( 4 ) -induced release
Salvatore et al., Proc Natl Acad Sci U S A 2008 : Our data provide evidence that l-arg counteracts detrimental effects induced by TNF or Bartonella infections via NO ( confirmed by DETA-NO and L-NMMA experiments ) and by modulation of p38 kinase phosphorylation
Beidelschies et al., J Cell Physiol 2008 : Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK
Buck et al., Biochem Pharmacol 2008 (Leukemia, Erythroblastic, Acute...) : An analysis of distinct signaling pathway activations then revealed an activation of p38 by TNF , as well as a corresponding involvement of this mitogen activated protein kinase ( MAPK ) in the cytokine dependent inhibition of erythroid differentiation
Suh et al., Vascul Pharmacol 2009 (MAP Kinase Signaling System) : Furthermore, Western blot analysis indicated that the TNF-alpha induced phosphorylation of extracellular signal regulated kinase 1 and 2 ( ERK1/2 ), p38 and c-Jun N-terminal kinase (JNK) were strongly inhibited by DPT
El-Remessy et al., Molecular vision 2008 (Uveitis) : This was followed by p38 MAPK activation and resulted in a time dependent increase in TNF-alpha production
Morin et al., Am J Respir Cell Mol Biol 2010 (Pneumonia) : Western blot analysis revealed that 17,18-EpETE pretreatment reversed the phosphorylation of p38 mitogen activated protein kinase ( p38-MAPK ) induced by TNF-a in human bronchi
Schlickeiser et al., J Immunol 2011 : Interestingly, all PHA-L ( high ) DCs displayed a strongly reduced responsiveness to TNF-a induced p38-MAPK activation compared with PHA-L ( low ) DCs, indicating differences in PHA-L binding capacities between DCs with different inflammatory properties
Chen et al., Vascul Pharmacol 2011 : However, ZLJ-6 did not affect TNF-a induced extracellular signal regulated kinases ( ERK1/2 ), c-Jun N-terminal kinases (JNK) and p38 phosphorylation
Guma et al., J Exp Med 2011 (Inflammation...) : Inflammation is driven by massive TNF production, which requires additional activation of p38 and extracellular-signal regulated kinase mitogen activated protein kinases ( MAPKs )
Ghosh et al., Infect Immun 2011 : By focusing on mitogen activated protein kinases, we show that both extracellular signal regulated kinase 1/2 and p38 , but not JNK, are required for hBD-, TNF-a- , and IL-1ß induced secretion of CCL20 by HOECs
Xie et al., J Nutr Biochem 2012 (MAP Kinase Signaling System) : This compound effectively inhibited the expression of proinflammatory cytokines TNF-a and IL-6 in low micromole levels by inhibiting NF-?B activation and p38 and JNK phosphorylation
Lee et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2012 : Furthermore, Tat mediated p66shc transduction augmented TNF-a induced p38 MAPK phosphorylation in endothelial cells
Norsted Gregory et al., J Neurosci Res 2013 : Furthermore, we show that pentoxifylline and propentofylline also inhibit JNK and p38 , but not ERK, activation induced by TNF
Modur et al., J Biol Chem 1996 : TNF additionally caused rapid p38 and JNK-1 mitogen activated protein kinase activation and efficient NF-kappaB translocation, which could not be achieved even by high levels of ceramide
Hazzalin et al., Mol Cell Biol 1998 : These data show that anisomycin behaves like a true signalling agonist and suggest that the anisomycin desensitized signalling component ( s ) is not involved in JNK/SAPK or p38/RK activation by EGF, bFGF, TNF-alpha , or TPA but may play a significant role in UV- and hyperosmolarity stimulated responses
Scheid et al., Blood 1999 : A selective p38 MAPK inhibitor, SB203580, blocked TNF -- or ceramide induced CREB phosphorylation, but had no effect on the induction of apoptosis mediated by these agents
Schafer et al., J Immunol 1999 : Furthermore, unlike LPS stimulated monocytes, TNF-alpha production by T cells is only partially p38 dependent