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NOS2 — PARP1

Text-mined interactions from Literome

Hassa et al., J Biol Chem 2001 : Finally, we showed that PARP-1 is activating the natural inducible nitric-oxide synthase and P-selectin promoter in a kappa B-dependent manner upon stimulation of the cells with inflammatory stimuli or cotransfection of p65
Wang et al., Ann N Y Acad Sci 2003 (Disease Models, Animal...) : The mechanisms of MPTP induced neurotoxicity are not yet fully understood but involve activation of N-methyl-D-aspartate ( NMDA ) receptors by glutamate, production of NO by nNOS and iNOS , oxidative injury to DNA, and activation of the DNA damage sensing enzyme poly ( ADP-ribose ) polymerase ( PARP )
Nakajima et al., J Biol Chem 2004 (Inflammation) : PARP-1 inhibitors and the antisense RNA for PARP-1 mRNA suppressed lipopolysaccharide (LPS) induced expression of tumor necrosis factor-alpha and inducible nitric-oxide synthase , suggesting that PARP-1 activity has a critical role in synthesis
Penberthy et al., Curr Drug Metab 2007 (Autoimmune Diseases) : Chronic elevation of TNFalpha leading to necrotic events by NAD depletion in autoimmune disease likely occurs via combination of persistent IDO activation and iNOS-peroxynitrate activation of PARP1 both of which deplete NAD
Kujundzić et al., Immunol Lett 2008 : Inhibition of poly ( ADP-ribose ) polymerase ( PARP ), a nuclear enzyme involved in DNA repair, replication and transcription, which cleaves NAD into nicotinamide and ADP-ribose, down regulated iNOS gene transcription and NO production in ChIFN-gamma stimulated HD11 cells
von Lukowicz et al., Cardiovasc Res 2008 (Atherosclerosis...) : PARP inhibition or PARP1 deletion reduced PARP activity and diminished expression of inducible nitric oxide synthase , vascular cell adhesion molecule-1, and P- and E-selectin
Naura et al., Eur Respir J 2009 (Eosinophilia) : iNOS expression was required for oxidative DNA damage and PARP-1 activation upon allergen challenge ... PARP-1 was required for iNOS expression and protein nitration, and this requirement was connected to nuclear factor-kappaB
Huang et al., Biochem Biophys Res Commun 2009 (Disease Models, Animal...) : Minocycline repressed the expression of TNF-alpha, IL-1beta, and iNOS , decreased the apoptotic index, and inhibited poly(ADP-ribose) polymerase-1 ( PARP-1 ) activity in the mouse small intestine
Mittal et al., Mol Cell Biochem 2011 (Respiratory Distress Syndrome, Adult) : Therefore, surfactant may regulate lung homeostasis by neutralizing acidic microenvironment in inflammatory lesions that leads to the upregulation of iNOS activity through the activation of NF-?B pathway and by PARP activation
Qin et al., Biochim Biophys Acta 2013 (Inflammation) : Moreover, PARP-1 inhibition attenuated LSS induced iNOS and ICAM-1 upregulation by inhibiting nuclear factor kappa B ( NF-?B ) nuclear translocation and activity, with a reduced NF-?B phosphorylation
Czapski et al., Neurochem Int 2013 (Inflammation) : PARP activity plays a role in regulation of expression of iNOS , the main enzyme responsible for oxidative/nitrosative stress in SIR