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ANGPT2 — RAC2

Text-mined interactions from Literome

Seshiah et al., Circ Res 2002 : These results suggest that c-Src, EGF receptor transactivation, phosphatidylinositol-3-kinase, and Rac play important roles in the sustained Ang II-mediated activation of vascular smooth muscle cell NAD ( P ) H oxidases and provide insight into the integrated signaling mechanisms whereby Ang II stimulation leads to activation of the growth related NAD ( P ) H oxidases
Fujii et al., J Biol Chem 2005 : Ang II-induced NFAT activation was suppressed by diphenyleneiodonium ( an NADPH oxidase inhibitor ), dominant negative ( DN ) -Rac , DN-p47(phox), and an inhibitor of Galpha(12/13) ( Galpha(12/13)-specific regulator of G protein signaling domain of p115RhoGEF, p115-regulator of G protein signaling (RGS) )
El Bekay et al., J Mol Endocrinol 2007 : Here, we describe that Ang II induced both Rac2 translocation from the cytosol to the plasma membrane and Rac2 GTP binding activity ... These results provide evidence that the activation of Rac2 by Ang II is exerted through multiple signalling pathways, involving Ca(2) ( + ) /calcineurin and protein kinases, the elucidation of which should be insightful in the design of new therapies aimed at reversing the inflammation of vessel walls found in a number of cardiovascular diseases