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CCK — NFKB1

Text-mined interactions from Literome

Han et al., Am J Physiol 1999 : Cholecystokinin induction of mob-1 chemokine expression in pancreatic acinar cells requires NF-kappaB activation
Han et al., Am J Physiol Cell Physiol 2001 : CCK independently activates intracellular trypsinogen and NF-kappaB in rat pancreatic acinar cells ... However, CCK stimulated NF-kappaB activation in Chinese hamster ovary-CCK ( A ) cells, which do not express trypsinogen, indicating that trypsin is not necessary for CCK activation of NF-kappaB
Gukovsky et al., Am J Physiol Gastrointest Liver Physiol 2003 (Pancreatitis, Alcoholic) : Curcumin also blocked CCK induced NF-kappaB and AP-1 activation in isolated pancreatic acini
Gukovskaya et al., Am J Physiol Gastrointest Liver Physiol 2004 : To elucidate the mechanism of sensitization, here we investigate the effect of ethanol on Ca ( 2+ ) - and PKC mediated pathways of CCK induced NF-kappaB activation using an in vitro system of rat pancreatic acini incubated with ethanol ... Ethanol augmented CCK-8 induced activation of NF-kappaB , similar to our in vivo findings with ethanol fed rats ... Pharmacological analysis showed that NF-kappaB activation by thapsigargin but not by CCK-8 is mediated through the calcineurin pathway and that the inhibitory effect of ethanol on the thapsigargin induced NF-kappaB activation could be through inhibiting this pathway ... Inhibitory analysis demonstrated that Ca ( 2+ ) -independent ( novel and/or atypical ) PKC isoforms are involved in NF-kappaB activation induced by both CCK-8 and PMA in cells treated and not treated with ethanol
Gukovsky et al., Gastroenterology 2004 : CCK induced intracellular Ca ( 2+ ) mobilization, Ca ( 2+ ) influx, trypsinogen, and NF-kappa B activation were all diminished in pancreatic acini isolated from p110 gamma ( -/- ) mice
Satoh et al., Am J Physiol Gastrointest Liver Physiol 2004 : PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells ... Inhibition of the novel PKC isoforms but not the conventional or the atypical isoform resulted in the prevention of NF-kappaB activation induced by CCK-8 and TNF-alpha ... NF-kappaB activation by CCK-8 and TNF-alpha required translocation but not tyrosine phosphorylation of PKC-delta
Gao et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006 : The inhibitory effects of CCK-8 on NF-kappaB p65 protein expression were attenuated by proglumide > CR-2945 > CR-1409
Satoh et al., Am J Physiol Gastrointest Liver Physiol 2006 : Previously, we demonstrated that in vitro ethanol treatment of pancreatic acinar cells augmented the CCK-8 induced activation of NF-kappaB , a key signaling system involved in the inflammatory response of pancreatitis ... Dispersed rat pancreatic acini were treated with and without ethanol and then stimulated with CCK-8 ; 100 nM CCK-8 caused both NF-kappaB and PKC-delta, -epsilon, and -zeta activation, whereas 0.1 nM CCK-8 did not increase PKC-epsilon, PKC-zeta, or NF-kappaB activity ... Of note, stimulation of acini with ethanol and 0.1 nM CCK-8 resulted in the activation of PKC-delta, PKC-epsilon, and NF-kappaB ... These results suggest that ethanol enhances the CCK-8 induced NF-kappaB activation at least in part through its effects on PKC-epsilon
Li et al., Shock 2007 : Furthermore, CCK-8 treatment activated the cyclic adenosine monophosphate-protein kinase A signaling pathway and H-89 ( a protein kinase A inhibitor ), abrogated the inhibitory effects of CCK-8 on p38 kinase activation and NF-kappaB activation ... Taken together, our results indicate that the stimulation of cyclic adenosine monophosphate-protein kinase A signaling pathway by CCK-8 through CCK-1R and CCK-2R inhibits the LPS induced activation of p38 kinase and NF-kappaB to block the IL-1beta production in rat pulmonary interstitial macrophages
Yuan et al., Am J Physiol Gastrointest Liver Physiol 2008 (Pancreatitis) : Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells ... Previous studies in our laboratory demonstrated that protein kinase C ( PKC ) isoforms PKCdelta and epsilon are key regulators of NF-kappaB activation induced by cholecystokinin-8 (CCK-8) , tumor necrosis factor-alpha, and ethanol ... Here, we demonstrate that protein kinase D1 (PKD1) is a key downstream target of PKCdelta and PKCepsilon in pancreatic acinar cells stimulated by two major secretagogues, CCK-8 and the cholinergic agonist carbachol ( CCh ), and that PKD1 is necessary for NF-kappaB activation induced by CCK-8 and CCh